学龄前儿童肺炎链球菌和卡他莫拉菌携带状态及影响因素分析

doi:10.7499/j.issn.1008-8830.2204163

Abstract
Figure/Table
References(20)
Related Citation (15)
Read Tracking
Download Tracking

Download: PDF (851 KB) HTML
Export: BibTeX | EndNote (RIS) Supporting Info

Abstract Objective To investigate the carriage status of Streptococcus pneumoniae (S. pneumoniae) and Moraxella catarrhalis (M. catarrhalis) in preschool children and the influencing factors for the carriage status. Methods The stratified cluster sampling method was used to select 2 031 healthy children from seven kindergartens in Shunde District of Foshan in Guangdong, China. Nasal swabs were collected from all children for the isolation and identification of S. pneumoniae and M. catarrhalis. The carriage status of S. pneumoniae and M. catarrhalis was analyzed in terms of its association with demographic features and hospital- and community-related factors. Results The carriage rates of S. pneumoniae and M. catarrhalis were 21.81% and 52.44%, respectively among the children. The co-carriage rate of S. pneumoniae and M. catarrhalis was 14.87%. The correspondence analysis showed that the factors such as lower grade, non-local registered residence, living in rural areas, small living area, history of respiratory tract infection but no history of antibiotic use, allergic skin diseases, and no hospital-related exposure history were significantly associated with the co-carriage of S. pneumoniae and M. catarrhalis among the children (P<0.05). Conclusions Co-carriage of S. pneumoniae and M. catarrhalis can be observed in preschool children. Young age, poor living environment, a history of respiratory tract infection but no history of antibiotic use, allergic skin diseases, and no hospital-related exposure history are important risk factors for the co-carriage of S. pneumoniae and M. catarrhalis in preschool children.

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	DENG Wen-Jun
	ZHANG Jing-Feng
	LI Ping-Yuan
	ZHOU Jun-Li
	YAO Zhen-Jiang
	YE Xiao-Hua

Key words： Streptococcus pneumoniae Moraxella catarrhalis Influencing factor Child

Received: 26 April 2022

Corresponding Authors: Ye X-H, Email: smalltomato@163.com E-mail: smalltomato@163.com

Cite this article:

DENG Wen-Jun,ZHANG Jing-Feng,LI Ping-Yuan et al. Co-carriage of Streptococcus pneumoniae and Moraxella catarrhalis among preschool children and its influencing factors[J]. CJCP, 2022, 24(8): 874-880.

URL:

http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2204163 OR http://www.zgddek.com/EN/Y2022/V24/I8/874

	Narwortey DK, Owusu-Ofori A, Slotved HC, et al. Nasopharyngeal carriage of Streptococcus pneumoniae among healthy children in Kassena-Nankana districts of Northern Ghana[J]. BMC Infect Dis, 2021, 21(1): 661. PMID: 34233627. PMCID: PMC8265090. DOI: 10.1186/s12879-021-06302-5.
	Hare KM, Seib KL, Chang AB, et al. Antimicrobial susceptibility and impact of macrolide antibiotics on Moraxella catarrhalis in the upper and lower airways of children with chronic endobronchial suppuration[J]. J Med Microbiol, 2019, 68(8): 1140-1147. PMID: 31274402. DOI: 10.1099/jmm.0.001033.
	Perez AC, Pang B, King LB, et al. Residence of Streptococcus pneumoniae and Moraxella catarrhalis within polymicrobial biofilm promotes antibiotic resistance and bacterial persistence in vivo[J]. Pathog Dis, 2014, 70(3): 280-288. PMID: 24391058. PMCID: PMC3984603. DOI: 10.1111/2049-632X.12129.
	Pan H, Cui B, Huang Y, et al. Nasal carriage of common bacterial pathogens among healthy kindergarten children in Chaoshan region, southern China: a cross-sectional study[J]. BMC Pediatr, 2016, 16(1): 161. PMID: 27741941. PMCID: PMC5064895. DOI: 10.1186/s12887-016-0703-x.
	Fadlyana E, Dunne EM, Rusmil K, et al. Risk factors associated with nasopharyngeal carriage and density of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus in young children living in Indonesia[J]. Pneumonia (Nathan), 2018, 10: 14. PMID: 30603377. PMCID: PMC6305570. DOI: 10.1186/s41479-018-0058-1.
	Amatya N, Paudel G, Saud B, et al. Prevalence of Moraxella Catarrhalis as a nasal flora among healthy kindergarten children in Bhaktapur, Nepal[J]. Interdiscip Perspect Infect Dis, 2022, 2022: 3989781. PMID: 35378873. PMCID: PMC8976674. DOI: 10.1155/2022/3989781.
	Oishi T, Muratani T, Tanaka T, et al. Study of normal flora in the pharynx of healthy children[J]. Jpn J Infect Dis, 2021, 74(5): 450-457. PMID: 33642434. DOI: 10.7883/yoken.JJID.2020.824.
	Han SB, Kim JH, Kang JH, et al. Recent epidemiology of Streptococcus pneumoniae in nasopharynxes of Korean children with acute otitis media[J]. J Infect Chemother, 2017, 23(3): 136-141. PMID: 28024738. DOI: 10.1016/j.jiac.2016.10.006.
	Im?hl M, Perniciaro S, Busse A, et al. Bacterial spectrum of spontaneously ruptured otitis media in a 7-year, longitudinal, multicenter, epidemiological cross-sectional study in Germany[J]. Front Med (Lausanne), 2021, 8: 675225. PMID: 34095179. PMCID: PMC8172772. DOI: 10.3389/fmed.2021.675225.
	Abaye G, Fekadu H, Haji K, et al. Prevalence and risk factors of pneumococcal nasopharyngeal carriage in healthy children attending kindergarten, in district of Arsi Zone, South East, Ethiopia[J]. BMC Res Notes, 2019, 12(1): 253. PMID: 31064380. PMCID: PMC6505268. DOI: 10.1186/s13104-019-4283-3.
	Silva MD, Lima A, Mar?al N, et al. Identification of the bacterial pathogens in children with otitis media: a study in the northwestern Portuguese district of Braga[J]. Microorganisms, 2021, 10(1): 54. PMID: 35056502. PMCID: PMC8779683. DOI: 10.3390/microorganisms10010054.
	Hu J, Sun X, Huang Z, et al. Streptococcus pneumoniae and Haemophilus influenzae type b carriage in Chinese children aged 12-18 months in Shanghai, China: a cross-sectional study[J]. BMC Infect Dis, 2016, 16: 149. PMID: 27080523. PMCID: PMC4831093. DOI: 10.1186/s12879-016-1485-3.
	Bayu D, Mekonnen A, Mohammed J, et al. Magnitude of Streptococcus pneumoniae among under-five children with symptom of acute respiratory infection at Hiwot Fana Specialized University Hospital, Harar, Ethiopia: associated risk factors and antibacterial susceptibility patterns[J]. Risk Manag Healthc Policy, 2020, 13: 2919-2925. PMID: 33328771. PMCID: PMC7734074. DOI: 10.2147/RMHP.S283860.
	14 邝兆威. 东莞地区学龄前儿童肺炎链球菌携带的调查分析[J]. 国际检验医学杂志, 2016, 37(14): 1973-1974. DOI: 10.3969/j.issn.1673-4130.2016.14.029.
	Maleki A, Mirnaseri Z, Kouhsari E, et al. Asymptomatic carriers of Neisseria meningitidis and Moraxella catarrhalis in healthy children[J]. New Microbes New Infect, 2020, 36: 100691. PMID: 32514361. PMCID: PMC7267740. DOI: 10.1016/j.nmni.2020.100691.
	Huebner RE, Wasas A, Mushi A, et al. Nasopharyngeal carriage and antimicrobial resistance in isolates of Streptococcus pneumoniae and Haemophilus influenzae type b in children under 5 years of age in Botswana [J]. Int J Infect Dis, 1998, 3(1): 18-25. PMID: 9831671. DOI: 10.1016/s1201-9712(98)90090-x.
	Birindwa AM, Emg?rd M, Nordén R, et al. High rate of antibiotic resistance among pneumococci carried by healthy children in the eastern part of the Democratic Republic of the Congo[J]. BMC Pediatr, 2018, 18(1): 361. PMID: 30453916. PMCID: PMC6241069. DOI: 10.1186/s12887-018-1332-3.
	Schwager MJ, Song Y, Laing IA, et al. Increased nasal Streptococcus pneumoniae presence in western environment associated with allergic conditions in Chinese immigrants[J]. Int J Hyg Environ Health, 2021, 234: 113735. PMID: 33725492. DOI: 10.1016/j.ijheh.2021.113735.
	Alnahas S, Hagner S, Raifer H, et al. IL-17 and TNF-α are key mediators of Moraxella catarrhalis triggered exacerbation of allergic airway inflammation[J]. Front Immunol, 2017, 8: 1562. PMID: 29184554. PMCID: PMC5694487. DOI: 10.3389/fimmu.2017.01562.
	Chapman TJ, Morris MC, Xu L, et al. Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children[J]. PLoS One, 2020, 15(12): e0243942. PMID: 33306743. PMCID: PMC7732056. DOI: 10.1371/journal.pone.0243942.