应用于新生儿缺氧缺血性脑病的脑电背景分析新方法

doi:10.7499/j.issn.1008-8830.2208102

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Abstract Objective To explore a new method for electroencephalography (EEG) background analysis in neonates with hypoxic-ischemic encephalopathy (HIE) and its relationship with clinical grading and head magnetic resonance imaging (MRI) grading. Methods A retrospective analysis was performed for the video electroencephalography (vEEG) and amplitude-integrated electroencephalography (aEEG) monitoring data within 24 hours after birth of neonates diagnosed with HIE from January 2016 to August 2022. All items of EEG background analysis were enrolled into an assessment system and were scored according to severity to obtain the total EEG score. The correlations of total EEG score with total MRI score and total Sarnat score (TSS, used to evaluate clinical gradings) were analyzed by Spearman correlation analysis. The total EEG score was compared among the neonates with different clinical gradings and among the neonates with different head MRI gradings. The receiver operating characteristic (ROC) curve and the area under thecurve (AUC) were used to evaluate the value of total EEG score in diagnosing moderate/severe head MRI abnormalities and clinical moderate/severe HIE, which was then compared with the aEEG grading method. Results A total of 50 neonates with HIE were included. The total EEG score was positively correlated with the total head MRI score and TSS (rs=0.840 and 0.611 respectively, P<0.001). There were significant differences in the total EEG score between different clinical grading groups and different head MRI grading groups (P<0.05). The total EEG score and the aEEG grading method had an AUC of 0.936 and 0.617 respectively in judging moderate/severe head MRI abnormalities (P<0.01) and an AUC of 0.887 and 0.796 respectively in judging clinical moderate/severe HIE (P>0.05). The total EEG scores of ≤6 points, 7-13 points, and ≥14 points were defined as mild, moderate, and severe EEG abnormalities respectively, which had the best consistency with clinical grading and head MRI grading (P<0.05). Conclusions The new EEG background scoring method can quantitatively reflect the severity of brain injury and can be used for the judgment of brain function in neonates with HIE.

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	Articles by authors
	FANG Xiu-Ying
	TIAN Yi-Li
	CHEN Shu-Yuan
	SHI Quan
	ZHENG Duo
	WANG Ying-Jie
	MAO Jian

Key words： Hypoxic-ischemic encephalopathy Electroencephalography Amplitude-integrated electroencephalography Neonate

Received: 17 August 2022

Cite this article:

FANG Xiu-Ying,TIAN Yi-Li,CHEN Shu-Yuan et al. A novel method for electroencephalography background analysis in neonates with hypoxic-ischemic encephalopathy[J]. CJCP, 2023, 25(2): 128-134.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2208102 OR http://www.zgddek.com/EN/Y2023/V25/I2/128

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