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CJCP  2024, Vol. 26 Issue (3): 289-296    DOI: 10.7499/j.issn.1008-8830.2309004
EXPERIMENTAL RESEARCH Current Issue| Next Issue| Archive| Adv Search  | 
Functional MRI assessment of microstructural and perfusion changes in the kidneys of rats with intrauterine growth restriction
LIANG Can, LI Ying, HE Xiao-Ri
Department of Neonatology, Second Xiangya Hospital, Central South University, Changsha 410011, China
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Abstract  Objective To explore the value of functional magnetic resonance imaging (MRI) techniques, including intravoxel incoherent motion (IVIM), T1 mapping, and T2 mapping, in assessing the microstructural and perfusion changes in the kidneys of rats with intrauterine growth restriction (IUGR). Methods An IUGR rat model was established through a low-protein diet during pregnancy. Offspring from pregnant rats on a low-protein diet were randomly divided into an IUGR 8-week group and an IUGR 12-week group, while offspring from pregnant rats on a normal diet were divided into a normal 8-week group and a normal 12-week group (n=8 for each group). The apparent diffusion coefficient (ADC), true diffusion coefficient (Dt), pseudo-diffusion coefficient (D*), perfusion fraction (f), T1 value, and T2 value of the renal cortex and medulla were compared, along with serum creatinine and blood urea nitrogen levels among the groups. Results The Dt value in the renal medulla was higher in the IUGR 12-week group than in the IUGR 8-week group, and the D* value in the renal medulla was lower in the IUGR 12-week group than in both the normal 12-week group and the IUGR 8-week group (P<0.05). The T1 value in the renal medulla was higher than in the cortex in the IUGR 8-week group, and the T1 value in the renal medulla was higher in the IUGR 12-week group than in both the IUGR 8-week group and the normal 12-week group, with the cortical T1 value in the IUGR 12-week group also being higher than that in the normal 12-week group (P<0.05). The T2 values in the renal medulla were higher than those in the cortex across all groups (P<0.05). There were no significant differences in the T2 values of either the cortex or medulla among the groups (P>0.05). There were no significant differences in serum creatinine and blood urea nitrogen levels among the groups (P>0.05). Glomerular hyperplasia and hypertrophy without significant fibrotic changes were observed in the IUGR 8-week group, whereas glomerular atrophy, cystic stenosis, and interstitial inflammatory infiltration and fibrosis were seen in the IUGR 12-week group. Conclusions IVIM MRI can be used to assess and dynamically observe the microstructural and perfusion damage in the kidneys of IUGR rats. MRI T1 mapping can be used to evaluate kidney damage in IUGR rats, and the combination of MRI T1 mapping and T2 mapping can further differentiate renal fibrosis in IUGR rats.
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LIANG Can
LI Ying
HE Xiao-Ri
Key wordsIntrauterine growth restriction      Kidney      Intravoxel incoherent motion      T1 mapping      T2 mapping      Functional magnetic resonance imaging      Rat     
Received: 04 September 2023     
Cite this article:   
LIANG Can,LI Ying,HE Xiao-Ri. Functional MRI assessment of microstructural and perfusion changes in the kidneys of rats with intrauterine growth restriction[J]. CJCP, 2024, 26(3): 289-296.
LIANG Can,LI Ying,HE Xiao-Ri. Functional MRI assessment of microstructural and perfusion changes in the kidneys of rats with intrauterine growth restriction[J]. CJCP, 2024, 26(3): 289-296.
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