Blood motilin and gastrin levels in term newborns with hyperbilirubinemia
AN Li, ZHAO Ping, WU Ji-Ying
Department of Pediatrics, Jinan Central Hospital, Clinical Medical College of Shandong University, Jinan 250013, China
Abstract OBJECTIVE: Most newborn infants with hyperbilirubinemia have gastrointestinal tract symptoms. The aim of this study is to investigate the effect of hyperbilirubinemia on gastrointestinal hormone levels in newborn infants. METHODS: Fasting plasma motilin and serum gastrin levels were measured using a radioimmunoassay in 50 term newborns with hyperbilirubinemia (Hyperbilirubinemia group). Fasting plasm motilin and serum gastrin levels from thirty normal term newborns were used as controls. RESULTS: The plasma motilin level in the Hyperbilirubinemia group (659±37 ng/L) was significantly higher than that of the controls (486±28 ng/L) (P< 0.01). The plasma motilin level was positively correlated with the serum bilirubin level. The serum gastrin level in the Hyperbilirubinema group was not different from that of the controls. CONCLUSIONS: The plasma motilin level is correlated with the level of bilirubin in the newborn. The abnormal increase in the level of motilin may be related to the development of gastrointestinal symptoms newborns with hyperbilirubinemia.
Key words :
Hyperbilirubinemia
Motilin
Gastrin
Radioimmunoassay
Infant, newborn
Cite this article:
AN Li,ZHAO Ping,WU Ji-Ying. Blood motilin and gastrin levels in term newborns with hyperbilirubinemia[J]. 中国当代儿科杂志, 2004, 6(4): 247-250.
AN Li,ZHAO Ping,WU Ji-Ying. Blood motilin and gastrin levels in term newborns with hyperbilirubinemia[J]. CJCP, 2004, 6(4): 247-250.
URL:
http://www.zgddek.com/EN/ OR http://www.zgddek.com/EN/Y2004/V6/I4/247
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