OBJECTIVE: Some research has shown that prolactin (PRL) is closely related to severity of hypoxic ischemic encephalopathy (HIE). However, the role of maternal and neonatal plasma PRL levels in neonatal asphyxia has not been reported so far. This paper aims at studying the changes of PRL levels in the cord blood, maternal blood and plasma of newborns in neonatal asphyxia. METHODS: The maternal blood, cord blood and neonatal plasma PRL levels in 25 neonates with asphyxia (asphyxia group) and 20 normal ones (control group) were detected by radioimmunoassay. RESULTS: The maternal blood, cord blood and neonatal plasma PRL levels [( 362.5 ± 127.1 ), ( 984.6 ± 262.3 ) and ( 386.3 ± 216.2 ) μg/L, respectively] in the asphyxia group were significantly higher than those in the control group [( 96.4 ± 26.2 ), ( 92.3 ± 18.4 ) and ( 68.7 ± 7.27 ) μg/L, respectively] (P< 0.01 ). The maternal blood, cord blood and neonatal plasma PRL levels [(445±216), (996±284) and (412±221) μg/L, respectively] in the severe asphyxia group were higher than those in the mild asphyxia group [(298±102), (612±221) and (309± 19.2 ) μg/L, respectively] (P< 0.01 or 0.05 ). The cord blood and neonatal plasma PRL levels had a positive correlation both in the mild and the severe asphyxia group (r= 0.54 , r=0.63, both P< 0.05 ). The plasma PRL level right after resuscitation was higher than that of the control group (P< 0.01 ). It gradually reduced from the 2nd day after birth, but was higher than that of the control group (P< 0.01 ). The PRL level on the 10th day after birth was not different from that of the control group. CONCLUSIONS: The PRL levels of neonatal plasma, cord blood and maternal blood increase in the perinatal asphyxial newborns. The plasma PRL level may be a good marker to evaluate the degree of asphyxia."/>
Changes of Maternal and Neonatal Plasma Prolactin Levels in Neonatal Asphyxia
Abstract OBJECTIVE: Some research has shown that prolactin (PRL) is closely related to severity of hypoxic ischemic encephalopathy (HIE). However, the role of maternal and neonatal plasma PRL levels in neonatal asphyxia has not been reported so far. This paper aims at studying the changes of PRL levels in the cord blood, maternal blood and plasma of newborns in neonatal asphyxia. METHODS: The maternal blood, cord blood and neonatal plasma PRL levels in 25 neonates with asphyxia (asphyxia group) and 20 normal ones (control group) were detected by radioimmunoassay. RESULTS: The maternal blood, cord blood and neonatal plasma PRL levels [( 362.5 ± 127.1 ), ( 984.6 ± 262.3 ) and ( 386.3 ± 216.2 ) μg/L, respectively] in the asphyxia group were significantly higher than those in the control group [( 96.4 ± 26.2 ), ( 92.3 ± 18.4 ) and ( 68.7 ± 7.27 ) μg/L, respectively] (P< 0.01 ). The maternal blood, cord blood and neonatal plasma PRL levels [(445±216), (996±284) and (412±221) μg/L, respectively] in the severe asphyxia group were higher than those in the mild asphyxia group [(298±102), (612±221) and (309± 19.2 ) μg/L, respectively] (P< 0.01 or 0.05 ). The cord blood and neonatal plasma PRL levels had a positive correlation both in the mild and the severe asphyxia group (r= 0.54 , r=0.63, both P< 0.05 ). The plasma PRL level right after resuscitation was higher than that of the control group (P< 0.01 ). It gradually reduced from the 2nd day after birth, but was higher than that of the control group (P< 0.01 ). The PRL level on the 10th day after birth was not different from that of the control group. CONCLUSIONS: The PRL levels of neonatal plasma, cord blood and maternal blood increase in the perinatal asphyxial newborns. The plasma PRL level may be a good marker to evaluate the degree of asphyxia.
LI Zhan-Kuai,FENG Jin-Xing,DUAN Zhao et al. Changes of Maternal and Neonatal Plasma Prolactin Levels in Neonatal Asphyxia[J]. 中国当代儿科杂志, 2003, 5(6): 505-508.
LI Zhan-Kuai,FENG Jin-Xing,DUAN Zhao et al. Changes of Maternal and Neonatal Plasma Prolactin Levels in Neonatal Asphyxia[J]. CJCP, 2003, 5(6): 505-508.
