Abstract OBJECTIVE: To explore the role of intercellular adhesion molecule-1 (ICAM-1) and regulated upon activation normal T cell expressed and secreted (RANTES) in bronchiolitis and their correlation in the pathogenesis of this disorder. METHODS: The expression of ICAM-1 was detected by flow cytometry on lymphocytes of peripheral blood in 28 infants with bronchiolitis, 23 infants with bronchopneumonia and 24 healthy infants. Serum level of RANTES was assayed using ELISA. The correlation between ICAM-1 and RANTES levels was evaluated using Pearson correlation coefficient. RESULTS: The ICAM-1 level in the bronchiolitis group (35.0±10.3%) was much higher than that in the bronchopneumonia (29.9±8.6%; P<0.05) and the control groups (24.6±6.9%; P<0.01). The bronchopneumonia group had higher ICAM-1 level than the control group (P<0.05). The RANTES level in the bronchiolitis (32.1±6.0 ng/mL) and the bronchopneumonia groups (30.6±6.2 ng/mL) was significantly higher than that in the control group (27.1±5.1 ng/mL) (P<0.01, P<0.05, respectively), however, no significant difference was found between the bronchopneumonia and bronchiolitis groups. There was a positive correlation between ICAM-1 and RANTES levels in the bronchiolitis group (r=0.675, P＜0.01). CONCLUSIONS: ICAM-1 and RANTES are involved in the pathogenesis of bronchiolitis and show a synergistic effect.［Chin J Contemp Pediatr, 2010, 12 (3):181-183］
［1］Reijonen TM, Kotaniemi-Syrjanen A, Korhonen K, Korppi M. Predictors of asthma three years after hospital admission for wheezing in infancy［J］. Pediatrics, 2000, 106(6):1406-1412．
［3］Kim HH, Lee MH, Lee JS. Eosinophil cationic protein and chemokines in nasopharyngeal secretions of infants with respiratory syncytial virus (RSV) bronchiolitis and non-RSV bronchiolitis［J］. J Korean Med Sci, 2007, 22(1):37-42.
［5］Lai CC, Tai HY, Shen HD, Chung WT, Chung RL,Tang RB.Elevated levels of soluble adhesion molecules in sera of patients with acute bronchiolitis［J］.J Microbiol Immunol Infect, 2004, 37（3）:153-156.
［8］Uchida O, Kajiwara N, Hayashi A, Miyajima K, Nagatsuka T, Hayashi H, et al. Met-RANTES ameliorates fibrous airway obliteration and decreases ERK expression in a murine model of bronchiolitis obliterans［J］. Ann Thorac Cardiovasc Surg, 2007, 13（2）:82-86.
［11］Tian M, Liu F, Wen GY, Shi SY, Chen RH, Zhao DY. Effect of variation in RANTES promoter on serum RANTES levels and risk of recurrent wheezing after RSV bronchiolitis in children from Han, Southern China［J］. Eur J Pediatr, 2009, 168(8)：963-967.
