Application of endotracheal lavage in neonatal ventilator-associated pneumonia

LIN Xin-Zhu, OU Yang-Chang-An, LAI Ji-Dong, LI Ya-Dan, ZHENG Zhi

Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (3) : 195-197.

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Chinese Journal of Contemporary Pediatrics ›› 2010, Vol. 12 ›› Issue (3) : 195-197.
CLINICAL RESEARCH

Application of endotracheal lavage in neonatal ventilator-associated pneumonia

  • LIN Xin-Zhu, OU Yang-Chang-An, LAI Ji-Dong, LI Ya-Dan, ZHENG Zhi
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Abstract

OBJECTIVE: To study the efficacy of endotracheal lavage in neonatal ventilator-associated pneumonia (VAP). METHODS: Fifty-eight neonates with VAP between January 2002 and December 2008 were randomly assigned to two groups: lavage and control (n=29 each). After withdrawal from ventilator, both groups received sensitive antibiotics therapy according to sputum culture results as well as supportive treatment. The lavage group was additionally treated with endotracheal lavage (2-3 times daily). The therapeutic effects were compared between the two groups. RESULTS: There were no significant differences in the average time of mechanical ventilation between the lavage and the control groups. The effective rate in the lavage group (93%) was significantly higher than that in the control group (69%; P<0.05). Three percent of patients in the lavage group required twice or more mechanical ventilation compared with 24% in the control group (P<0.05). Blood gas analysis results were obviously improved in the lavage group 2 hrs after treatment (P<0.01). CONCLUSIONS: Endotracheal lavage can decrease the number in mechanical ventilation and improve therapeutic effects in neonates with VAP.[Chin J Contemp Pediatr, 2010, 12 (3):195-197]

Key words

Ventilator-associated pneumonia / Mechanical ventilation / Neonate

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LIN Xin-Zhu, OU Yang-Chang-An, LAI Ji-Dong, LI Ya-Dan, ZHENG Zhi. Application of endotracheal lavage in neonatal ventilator-associated pneumonia[J]. Chinese Journal of Contemporary Pediatrics. 2010, 12(3): 195-197

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