Abstract OBJECTIVE: To compare the efficacy of sublingual immunotherapy (SLIT) combined with inhaled corticosteroids (ICS) versus ICS alone in children with mild and moderate dust mite allergic asthma. METHODS: Thirty-two children with mild and moderate dust mite allergic asthma were randomly divided into two groups: SLIT+ICS (n=18) and ICS alone (n=14). A total of 30 children completed the one year clinical observation . The amount of ICS administration, the day and night symptom scores, skin-prick test and pulmonary function test results, serum specific immunoglobulin E (sIgE) and G4 (sIgG4) levels and visual analog scale (VAS) scores were compared between the two groups. RESULTS: By the end of one year the SLIT+ICS group had significantly decreased amount of ICS administration than the ICS alone group. Compared with the ICS alone group, the day and night symptom scores decreased, FEF25-75% increased significantly, and serum sIgE levels and VAS scores were significantly reduced in the SLIT+ICS group. There were no statistical differences in the skin-prick test results, and FEV1 and sIgG4 levels between the two groups. No severe adverse events occurred in both groups during the follow-up period. CONCLUSIONS: SLIT combined with ICS may produce a better efficacy than ICS alone in the improvement of day and night symptoms, pulmonary function and VAS scores in children with dust mite-allergic asthma.［Chin J Contemp Pediatr, 2010, 12 (5):344-347］
［1］Pocket Guide For Asthma Management and Prevention（updated 2008）: Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA) ［EB/OL］.
［2］HalloyJL. Sublingual hyposensitization［J］. Rev Med Brux, 2004, 25(4):A256-258.
［3］Abramson M, Puy R, Weiner J. Allergen immunotherapy for asthma［J］. Cochrane Database of Systematic Reviews, 2003, 4: CD001186.
［4］Di Rienzo V, Marcucci F, Puccinelli P, Parmiani S, Frati F, Sensi L, et al. Long-lasting effect of sublingual immunotherapy in children with asthma due to house dust mite: a 10-year prospective study［J］.Clin Exp Allergy, 2003, 33(2): 206-210.
［5］Calamita Z, Saconato H, Pela AB, Atallah AN. Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method［J］. Allergy, 2006, 61(10): 1162-1172.
［7］Penagos M, Passalacqua G, Compalati E, Baena-Cagnani CE, Orozco S, Pedroza A, et al. Meta analysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age［J］. Chest, 2008, 133(3):599-609.
