Abstract OBJECTIVE: This study examined the biochemical metabolism by proton magnetic resonance spectroscopy ('H-MRS) in order to explore the value of 'H-MRS in idiopathic epilepsy in children. METHODS: Thirty-three children with idiopathic epilepsy (14 cases with history of febrile seizures and 19 cases without) and six normal controls experienced MRI of the skull and brain and single-voxel 'H-MRS examinations of the hippocampi-temporal lobe. The signal intensities of N-acetylaspartate (NAA), eatine+phosphocreatine (Cr), choline-containig compounds (Cho) and lactate (Lac) and the ratios of NAA/ (Cho+Cr) and Lac/Cr were compared between the patients and normal controls. RESULTS: MRI examination showed that only one child with epilepsy had myelin dysplasia. 'H-MRS examination showed that the ratio of NAA/ (Cho+Cr) in the epilepsy group was lower than that in the control group (0.64±0.07 vs 0.73±0.05; P＜0.01). The epileptic children with history of febrile seizures had a more decreased ratio of NAA/ (Cho+Cr) compared with those without the history (0.61±0.07 vs 0.66±0.06; P<0.05). There were no significant differences in the ratio of Lac/Cr between the epilepsy and the control groups. CONCLUSIONS: 'H-MRS may provide early information on brain injury sensitively and non-invasively in children with epilepsy. It may be used for diagnosis and prognosis evaluation of epilepsy.［Chin J Contemp Pediatr, 2010, 12 (6):425-428］
SHAO Xiao-Li,ZHOU Zhong-Shu,HONG Wen. Clinical application of proton magnetic resonance spectroscopy in children with idiopathic epilepsy[J]. 中国当代儿科杂志, 2010, 12(06): 425-428.
SHAO Xiao-Li,ZHOU Zhong-Shu,HONG Wen. Clinical application of proton magnetic resonance spectroscopy in children with idiopathic epilepsy[J]. CJCP, 2010, 12(06): 425-428.
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