Abstract OBJECTIVE: To study the effects of valproate sodium (VPA) on the level and axle of pituitary gonadotropin in adolescent girls with epilepsy. METHODS: Twenty-three adolescent girls with epilepsy aged from 8 to 14 years were treated with VPA for 1 year. The levels of serum pituitary gonadotropin including estradiol, follicle-stimulating hormone, luteinizing hormone, prolactin and testosterone were measured before treatment and 3 months, 6 months and 1 year after treatment. RESULTS: The serum levels of estradiol, follicle-stimulating hormone, luteinizing hormone and prolactin in the children with epilepsy were not significantly different during the 1 year VPA treatment compared with pretreatment. However, the serum level of testosterone was reduced 1 year after treatment (0.4±0.3 ng/mL) compared with pretreatment (0.7±0.4 ng/mL) and 3 months after treatment (0.7±0.4 ng/mL) (P＜0.05). CONCLUSIONS: VPA treatment for 1 year does not increase serum levels of androgen in adolescent girls with epilepsy, suggesting that VPA is an ideal choice of treatment for the girls.
［1］International League Against Epilepsy. ILAE Commission Report. The epidemiology of the epilepsies: future directions［J］.Epilepsia, 1997, 38(5):614-618.
［4］Herzog AG, Schachater SC. Valproate and the polycystic ovarian syndrome: final thoughts［J］. Epilepsia, 2001, 42(3):311-315.
［5］Herzog AG, Seibel MM, Schomer DL, Vaitukaitis JL, Geschwind N.Reproductive endocrine disorders in women with partial seizures of temporal lobe origin［J］.Arch Neurol, 1986, 43(4):341-346.
［6］Bilo L, Meo R, Nappi C, Annunziato L, Striano S, Colao AM, et al. Reproductive endocrine disorders in women with primary generalized epilepsy［J］. Epilepsia, 1988, 29(5):612-619.
［7］Isoj-rvi JI, Taub-ll E, Herzog AG. Effect of antiepileptic drugs on reproductive endocrine function in individuals with epilepsy［J］.CNS Drugs, 2005, 19(3):207-223.
［8］R-tty-J, Pakarinen AJ, Knip M, Repo-Outakoski M, Myllyl-VV, Isoj-rvi JI.Early hormonal changes during valproate or carbamazepine treatment: a 3-month study［J］. Neurology, 2001, 57(3):440-444.
［11］Herzog AG, Coleman AE, Jacobs AR, Klein P, Friedman MN, Drislane FW, et al. Relationship of sexual dysfunction to epilepsy laterality and reproductive hormone levels in women［J］.Epilepsy Behav, 2003, 4(4): 407-413.
［12］Taub-ll E, Gregoraszczuk EL, Kolodziej A, Kajta M, Ropstad E. Valproate inhibits the conversion of testosterone to estradiol and acts as an apoptotic agent in growing porcine ovarian follicular cells［J］. Epilepsia, 2003, 44(8):1014-1021.
［13］Nelson-DeGrave VL, Wickenheisser JK, Cockrell JE, Wood JR, Legro RS, Strauss JF 3rd, et al. Valproate potentiates androgen biosynthesis in human ovarian theca cells［J］. Endocrinology, 2004, 145(2):799-808.
［14］EI-Khayat HA, Abd EI-Basset FZ, Tomoun HY, Tohamy SM, Zaky AA, Mohamed MS, et al. Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy［J］. Epilepsia, 2004, 45(9):1106-1115.
