Abstract OBJECTIVE: To study the clinical features, diagnosis and therapy of thyroid neoplasm in children. METHODS: A retrospective study was performed on 32 children with thyroid nodular who were underwent operation in Xiangya Hospital between January 2002 and December 2010. RESULTS: Of the 32 cases, there were 23 girls and 9 boys. Six cases were diagnosed as nodular Goiter adenoma and 26 cases were diagnosed as thyroid papillary carcinoma. B-ultrasonic examination showed a 100% accurate rate for the diagnosis of thyroid carcinoma. Fourteen children (44%) were proven to have concurrent Hashimoto′s thyroiditis. Twenty-two (69%) children with thyroid carcinoma were found to have lymph metastasis in the lateral neck. The children younger than 10 years showed a high rate of metastasis than those older one (94% vs 56%, P＜0.05). All 32 children received a surgical therapy. Subtotal thyroidectomy was performed on the 6 children with nodular Goiter adenoma. Total thyroidectomy (17 cases) or ipsilateral thyroidectomy (9 cases) was performed according to the stage of thyroid carcinoma. The surgical outcomes were followed up for 3 months to 9 years and no recurrence or death occurred. The development and growth were normal in the children. CONCLUSIONS: Childhood thyroid nodular attacks girls more than boys, and the frequency of malignancy is high. Hashimoto′s thyroiditis is a common concurrent disease. The incidence of local lymph metastasis is high in those younger than 10 years. The surgical therapy for thyroid neoplasm may lead satisfactory outcomes in children.
CHANG Shi,DENG Zhen-Han,DONG Chao et al. Clinical features and experience of diagnosis and treatment of thyroid neoplasm in children[J]. 中国当代儿科杂志, 2011, 13(9): 736-739.
CHANG Shi,DENG Zhen-Han,DONG Chao et al. Clinical features and experience of diagnosis and treatment of thyroid neoplasm in children[J]. CJCP, 2011, 13(9): 736-739.
［1］O′Gorman CS, Hamilton J, Rachmiel M, Gupta A, Ngan BY, Daneman D. Thyroid cancer in childhood: a retrospective review of childhood course［J］. Thyroid, 2010, 20(4): 375-380.
［2］Atabek ME. What is the safe and accurate procedure for thyroid nodules in childhood?［J］. Horm Res Paediatr, 2011, 76(1): 72.
［3］Jonklaas J, Sarlis NJ, Litofsky D, Ain KB, Bigos ST, Brierley JD, et al. Outcomes of patients with differentiated thyroid carcinoma following initial therapy［J］. Thyroid, 2006, 16(12): 1229-1242.
［4］Feinmesser R, Lubin E, Segal K, Noyek A. Carcinoma of the thyroid in children—a review［J］. J Pediatr Endocrinol Metab, 1997, 10(6): 561-568.
［6］Kim EY, Kim WG, Kim WB, Kim TY, Kim JM, Ryu JS, et al. Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma［J］. Clin Endocrinol (Oxf), 2009, 71(4): 581-586.
［7］Brignardello E, Corrias A, Isolato G, Palestini N, Cordero di Montezemolo L, Fagioli F, et al. Ultrasound screening for thyroid carcinoma in childhood cancer survivors: a case series［J］. J Clin Endocrinol Metab, 2008, 93(12): 4840-4843.
［8］Pascanu I, Borda A, Banescu C. Thyroid nodule with Hashimoto thyroiditis in childhood—a challenging experience［J］. Rom J Morphol Embryol, 2008, 49(4): 541-545.
［9］Anil C, Goksel S, Gursoy A. Hashimoto′s thyroiditis is not associated with increased risk of thyroid cancer in patients with thyroid nodules: a single-center prospective study［J］. Thyroid, 2010, 20(6): 601-606.
［11］Karnak I, Ardíclí B, Ekinci S, Ciftci AO, Orhan D, Kale G, et al. Papillary thyroid carcinoma does not have standard course in children［J］. Pediatr Surg Int, 2010, 11(5):211-216.
［12］Kowalski LP, Gon-alves Filho J, Pinto CA, Carvalho AL, de Camargo B. Long-term survival rates in young patients with thyroid carcinoma［J］. Arch Otolaryngol Head Neck Surg, 2003, 129(7): 746-749.
［13］Carty SE, Cooper DS, Doherty GM, Duh QY, Kloos RT, Mandel SJ, et al. Consensus statement on the terminology and classification of central neck dissection for thyroid cancer［J］. Thyroid, 2009, 19(11): 1153-1158.
