Abstract OBJECTIVE: To study the epileptiform discharges and sleep structure in children with nocturnal epilepsy. METHODS: A total of 54 children with nocturnal epilepsy (NE group) between December 2009 and June 2011 were enrolled in this study using a cluster sampling method. Their epileptiform discharges and sleep structure were monitored using nocturnal 12 h-video-echoencephalography (EEG) and polysomnography. Meanwhile, 40 age- and gender-matched normal children were enrolled as the control group. RESULTS: All the 54 children in the NE group suffered from epileptiform discharges and a varied number of clinical seizures, especially at S1 and S2 states. Compared with the control group, S1 and S2 states had significantly higher proportions in the NE group, and S3 and S4 states and REM state had significantly lower proportions (P<0.01). CONCLUSIONS: Epileptiform discharges and clinical seizures are more common in children with nocturnal epilepsy, especially during the non-rapid eye movement sleep. Meanwhile, remarkably disordered sleep structure also exists.
NING Ze-Shu,ZHANG Jie,JIANG Zhi et al. Epileptiform discharges and sleep structure in children with nocturnal epilepsy[J]. 中国当代儿科杂志, 2012, 14(2): 124-127.
NING Ze-Shu,ZHANG Jie,JIANG Zhi et al. Epileptiform discharges and sleep structure in children with nocturnal epilepsy[J]. CJCP, 2012, 14(2): 124-127.
[2]Engel J Jr. International League Against Epilepsy (ILAE). A proposed diagnostic scheme for peoplewith epileptic seizures and with epilepsy: report of ILAE Task Force on Classification and Terminology[J]. Epilepsia, 2001, 42(6): 769-803.
[3]Rechtschaffen A, Kales A. A Manual of Satandardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects[M]. Washington DC: US Government Printing Offices, 1968.
[4]Wang WZ, Wu JZ, Wang DS, Dai XY, Xang B, Wang B, et al. The prevalence and treatment gap in epilepsy in China: an ILAE/IBE/WHO study[J]. Neurology, 2003, 60(9): 1544-1545.
[5]Holmes GL. The 2008 Judith Hoyer Lecture: epilepsy in children: listening to mothers[J]. Epilepsy Behav, 2009, 16(2): 193-202.
[6]Freitag CM, May TW, Pf-fflin M, Konig S, Rating D. Incidence of epilepsies and epileptic syndromes in children and adolescents: a population-based prospective study in Germany[J]. Epilepsia, 2001, 42(8): 979-985.
[7]Hofstra WA, Grootemarsink BE, Dieker R, van der Palen J, de Weerd AW. Temporal distribution of clinical seizures over the 24 h day: a retrospective observational study in a tertiary epilepsy clinic[J]. Epilepsia, 2009, 50(9): 2019-2026.
[8]Zarowski M, Loddenkemper T, Vendrame M, Alexopoulos AV, Wyllie E, Kothare SV. Circadian distribution and sleep/wake patterns of generalized seizures in children[J]. Epilepsia, 2011, 52(6): 1076-1083.
[13]Keller CJ, Truccolo W, Gale JT, Eskandar E, Thesen T, Carlson C, et al. Hetero geneous neuronal firing patterns during interictal epileptiform discharges in the human cortex[J]. Brain, 2010, 133(Pt 6): 1668-1681.
[14]Hirshkowitz M. Normal human sleep: an overview[J]. Med Clin North Am, 2004, 88(3): 551-565.
[15]de Almeida CA, Lins OG, Lins SG, Laurentino S, Valenca MM. Sleep disorders in temporal lobe epilepsy[J]. Arq Neuropsiquiatr, 2003, 61(4): 979-987.
[16]Lopez-Gom-riz E, Hoyo-Rodrigo B, Rodríguez-Nieto I. The effects of epileptic seizures on sleep architecture[J]. Rev Neurol, 2004, 38(2): 176-180.
[17]Rocamora R, Sonchez-Alvarez JC, Salas-Puig J. The relationship between sleep and epilepsy[J]. Neurologist, 2008, 14(6 Suppl 1): S35-S43.
[18]Nunes ML. Sleep and epilepsy in children: clinical aspects and polysomnography[J]. Epilepsy Res, 2010, 89(1): 121-125.
[19]Parisi P, Bruni O, Pia Villa M, Verrotti A, Miano S, Luchetti A, et al. The relationship between sleep and epilepsy: the effect on cognitive functioning in children[J]. Dev Med Child Neurol, 2010, 52(9): 805-810.