CT manifestations of liver involvement in children with Langerhans cell histiocytosis

LIU Hui, LONG Xue-Ying, LI Wen-Zheng, WANG Xiao-Yi, CAO Jue, LIU Zhi-Jun

Chinese Journal of Contemporary Pediatrics ›› 2013, Vol. 15 ›› Issue (2) : 121-124.

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Chinese Journal of Contemporary Pediatrics ›› 2013, Vol. 15 ›› Issue (2) : 121-124. DOI: 10.7499/j.issn.1008-8830.2013.02.012
CLINICAL RESEARCH

CT manifestations of liver involvement in children with Langerhans cell histiocytosis

  • LIU Hui, LONG Xue-Ying, LI Wen-Zheng, WANG Xiao-Yi, CAO Jue, LIU Zhi-Jun
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Abstract

OBJECTIVE: To investigate the computed tomography (CT) manifestations of liver involvement in children with Langerhans cell histiocytosis (LCH). METHODS: Retrospective analysis was performed on 9 LCH children with liver involvement confirmed by clinical, laboratory and pathological examinations to investigate the CT manifestations of this condition. These children, including 6 males and 3 females, had undergone both plain CT scan and dual-phase (the arterial and portal venous phases) contrast-enhanced CT scan. RESULTS: The main CT manifestations included hepatomegaly (8 cases); periportal dendritic hypodense lesions or “periportal halo sign” (7 cases) which were mildly or moderately enhanced in the arterial phase; intrahepatic bile duct dilatation (5 cases); lymphadenopathy in the hepatic hilar or retroperitoneal region (4 cases); and diffuse small hypodense nodules (3 cases), which showed annular enhancement on the contrastenhanced CT scan. CONCLUSIONS: CT findings may be helpful in the early diagnosis and treatment of LCH in children.

Key words

Langerhans cell histiocytosis / Liver / Tomography / X-ray computer / Child

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LIU Hui, LONG Xue-Ying, LI Wen-Zheng, WANG Xiao-Yi, CAO Jue, LIU Zhi-Jun. CT manifestations of liver involvement in children with Langerhans cell histiocytosis[J]. Chinese Journal of Contemporary Pediatrics. 2013, 15(2): 121-124 https://doi.org/10.7499/j.issn.1008-8830.2013.02.012

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