Non-high-density-cholesterol as a predictor of non-lipid cardiovascular disease risk factors in obese children

CHEN Lian-Hui; ZHU Wei-Fen; LIANG Li; FU Jun-Fen; WANG Chun-Lin; FANG Yan-Lan; CHEN Xue-Feng

doi:10.7499/j.issn.1008-8830.2013.05.009

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Chinese Journal of Contemporary Pediatrics ›› 2013, Vol. 15 ›› Issue (5) : 356-360. DOI: 10.7499/j.issn.1008-8830.2013.05.009

CLINICAL RESEARCH

Non-high-density-cholesterol as a predictor of non-lipid cardiovascular disease risk factors in obese children

CHEN Lian-Hui, ZHU Wei-Fen, LIANG Li, FU Jun-Fen, WANG Chun-Lin, FANG Yan-Lan, CHEN Xue-Feng

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Abstract

OBJECTIVE: To investigate the role of non-high density lipoprotein cholesterol (non-HDL-C) in the assessment of cardiovascular disease (CVD) risk factors such as hypertension, pre-diabetes and diabetes in obese children. METHODS: According to the presence of complications (hypertension, pre-diabetes and diabetes), 810 children with central obesity were divided into two groups: one group with complications (n=499) and one group without complications (n=311). One hundred and sixty-four age- and sex-matched children served as the control group. Logistic regression analysis and receiver operating characteristic (ROC) curves were used to analyze the detection of non-lipid CVD risk factors by seven lipid markers. RESULTS: The prevalence rates of hypertension and pre-diabetes were significantly higher in obese children with high non-HDL-C concentrations (≥3.76 mmol/L). After adjusting for waist circumference Z-scores, the area under the ROC curve for non-HDL-C was 0.680 to detect non-lipid CVD risk factors, while the areas for low-density lipoprotein cholesterol, total cholesterol and apoprotein B were 0.659, 0.669 and 0.647 respectively. CONCLUSIONS: Compared with the other lipid markers, non-HDL-C is a better predictor for non-lipid CVD risk factors in obese children. Measurement of non-HDL-C concentations is recommended for obese children.

Key words

Non-high-density lipoprotein cholesterol / Obesity / Hypertension / Diabetes / Child / Adolescent

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CHEN Lian-Hui, ZHU Wei-Fen, LIANG Li, FU Jun-Fen, WANG Chun-Lin, FANG Yan-Lan, CHEN Xue-Feng. Non-high-density-cholesterol as a predictor of non-lipid cardiovascular disease risk factors in obese children[J]. Chinese Journal of Contemporary Pediatrics. 2013, 15(5): 356-360 https://doi.org/10.7499/j.issn.1008-8830.2013.05.009

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