Significance of exhaled nitric oxide measurement in remitting childhood asthma with concurrent remitting rhinitis

LIU Sha; GONG Cai-Hui; FU Zhou

doi:10.7499/j.issn.1008-8830.2014.02.013

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Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (2) : 161-164. DOI: 10.7499/j.issn.1008-8830.2014.02.013

Significance of exhaled nitric oxide measurement in remitting childhood asthma with concurrent remitting rhinitis

LIU Sha, GONG Cai-Hui, FU Zhou

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Abstract

Objective To evaluate the value of exhaled nitric oxide in the severity evaluation of asthmatic children with remitting rhinitis. Methods A total of 214 asthmatic children were randomly allocated to a untreated control and a conventional treatment group. Patients in each of the two subclasses were classified as asthma with concurrent rhinitis and asthma without concurrent rhinitis. Values of the 20% fall in forced expiratory volume in 1 second (PC₂₀FEV₁) and fractional exhaled nitric oxide (FeNO) were measured. Results The PC₂₀FEV₁ level was significantly higher in untreated asthma patients without rhinitis than in those with concurrent rhinitis (P<0.05), while FeNO was not significantly different between these two groups (P>0.05). There were no significant differences in both FeNO and PC₂₀FEV₁ between treated asthma patients with and without concurrent rhinitis (P>0.05). PC₂₀FEV₁ was significantly increased (P<0.05) but FeNO was significantly decreased (P<0.05) in asthma patients with concurrent rhinitis after conventional treatment. In asthmatic children without concurrent rhinitis, treatment significantly decreased the level of FeNO (P<0.05) but had not effect on PC₂₀FEV₁ (P>0.05). Conclusions Exhaled nitric oxide measurement may be useful in the severity evaluation of asthmatic children with remitting rhinitis.

Key words

Exhaled nitric oxide / Asthma / Rhinitis / Clinical remission stage / Child

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LIU Sha, GONG Cai-Hui, FU Zhou. Significance of exhaled nitric oxide measurement in remitting childhood asthma with concurrent remitting rhinitis[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(2): 161-164 https://doi.org/10.7499/j.issn.1008-8830.2014.02.013

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