Abstract Objective To study the clinical effectiveness and safety of nasal intermittent positive pressure ventilation (NIPPV) in the initial treatment of neonatal respiratory distress syndrome (NRDS) and the initial setting of NIPPV parameters. Methods One hundred neonates with NRDS were divided into NIPPV group (n=50) and nasal continuous positive airway pressure (NCPAP) group (n=50). A randomized controlled study was conducted to compare the effectiveness of NIPPV versus NCPAP in the initial treatment of NRDS from the following aspects: reducing CO2 retention, improving oxygenation, reducing second endotracheal intubation and second use of pulmonary surfactant (PS), reducing the duration of invasive respiratory support, reducing the duration of oxygen use, and reducing the incidence of air leak, abdominal distension and ventilator-associated pneumonia. Results After 1 and 6 hours of noninvasive respiratory support, the NIPPV group was superior to the NCPAP group with respect to the reduction in CO2 retention and improvement in oxygenation (P2 >0.21, and significantly lower incidence of apnea and ventilator-associated pneumonia (PConclusions NIPPV is effective and safe in the initial treatment of NRDS and holds promise for clinical application.
Sai Sunil Kishore M, Dutta S, Kumar P. Early nasal intermittent positive pressure ventilation versus continuous positive airway pressure for respiratory distress syndrome[J]. Acta Paediatr, 2009, 98(9): 1412-1415.
[9]
Sankaran K, Adegbite M. Noninvasive respiratory support in neonates: a brief review[J].中国当代儿科杂志, 2012, 14(9): 644-652.
Owen LS, Morley CJ, Davis PG. Neonatal nasal intermittent positive pressure ventilation:what do we know in 2007?[J]. Arch Dis Child Fetal Neonatal Ed, 2007, 92(5): 414-418.
[1]
Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease [J]. Annu Rev Pharmacol Toxicol, 2000, 40(1): 581-616.
[13]
Owen LS, Morley CJ, Davis PG. Pressure variation during ventilator generated nasal intermittent positive pressure ventilation in preterm infants[J]. Arch Dis Child Fetal. Neonatal.Ed, 2010, 95(5): F359-F364.
[2]
Kaplan M, Hammerman C, Maisels MJ. Bilirubin genetics for the nongeneticist: hereditary defects of neonatal bilirubin conjugation [J]. Pediatrics, 2003, 111(4): 886-893.
