Inducible nitric oxide synthase and brain hypoxic-ischemic brain damage

LIU Hai-Ting; MU De-Zhi

doi:10.7499/j.issn.1008-8830.2014.09.022

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Chinese Journal of Contemporary Pediatrics ›› 2014, Vol. 16 ›› Issue (9) : 962-967. DOI: 10.7499/j.issn.1008-8830.2014.09.022

REVIEW

Inducible nitric oxide synthase and brain hypoxic-ischemic brain damage

LIU Hai-Ting^1,2, MU De-Zhi^1,2

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Abstract

Brain hypoxia-ischemia has been considered as critical factors in many human central nervous system diseases, including stroke and neonatal hypoxic-ischemic encephalopathy. In brain hypoxia-ischemia processes, inducible NO synthase（iNOS) is induced to produce excessive nitric oxide（NO) which leads to cascade reactions of inflammation and neuronal death, deteriorating primary brain injury. Inhibiting iNOS expression has opened new perspectives in the treatment of brain hypoxia-ischemia because iNOS inhibitor has been shown as a potent therapeutic agent. This reviews focus on recent research achievements regarding the relationship between iNOS and ischemic-hypoxic brain damage and the perspective of using iNOS inhibitors as therapeutic strategies for brain ischemic-hypoxic brain damage.

Key words

Inducible nitric oxide synthase / Nitric oxide / Hypoxic-hypoxic brain damage

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LIU Hai-Ting, MU De-Zhi. Inducible nitric oxide synthase and brain hypoxic-ischemic brain damage[J]. Chinese Journal of Contemporary Pediatrics. 2014, 16(9): 962-967 https://doi.org/10.7499/j.issn.1008-8830.2014.09.022

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