The comparison of clinical features in children with different control levels of asthma

XING Yan; LI Zuo-Fen; ZHOU Wei; LI Nan; LIU Ling; BAO Hui-Ling

doi:10.7499/j.issn.1008-8830.2015.02.006

PDF(1167 KB)

Chinese Journal of Contemporary Pediatrics ›› 2015, Vol. 17 ›› Issue (2) : 138-143. DOI: 10.7499/j.issn.1008-8830.2015.02.006

CLINICAL RESEARCH

The comparison of clinical features in children with different control levels of asthma

XING Yan¹, LI Zuo-Fen², ZHOU Wei¹, LI Nan³, LIU Ling¹, BAO Hui-Ling¹

Author information +

History +

Abstract

Objective To compare the clinical features in children with different control levels of asthma and to explore the factors influencing asthma control. Methods A cross-sectional study was performed on 115 children diagnosed with asthma between October 2013 and February 2014. All the patients were classified into two groups: fully controlled group (n=65) and non-fully controlled group (n=55), according to the Children Bronchial Asthma Prevention and Treatment Guideline (2008 version) and the asthma control test results. The differences of clinical features between the two groups were compared. The quality of life was evaluated by an asthma-related quality of life questionnaire. The main factors influencing asthma control were analyzed by the logistic regression method. Results There were significant differences in the frequencies of respiratory tract infection and acute asthma attacks within the 3 months, and unplanned hospital visits due to acute asthma attacks between the fully controlled and non-fully controlled groups (P<0.05). The scores of asthma-related quality of life in the fully controlled group were significantly lower than in the non-fully controlled group in children under 7 years old. In contrast, the scores of asthma-related quality of life in the fully controlled group were significantly higher than in the non-fully controlled group in children at the age of 7-16 years (P<0.05). The logistic regression analysis showed that the patients without experiencing regular hospital visits (OR=7.715) and with allergic rhinitis (OR=5.531) had increased risks for poor asthma control and that the patients with other allergic diseases (eg. eczema, food allergy) had decreased risks for poor asthma control (OR=0.299). Conclusions The appearance of some clinical features suggests that the asthmatic children may be in the status of poor asthma control and need an active intervention. A poor asthma control status can result in a decreased quality of life. To improve the asthma control level, the incidence of allergic rhinitis should be reduced and a regular hospital visit should be performed in the children.

Key words

Asthma / Control level / Child

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

XING Yan, LI Zuo-Fen, ZHOU Wei, LI Nan, LIU Ling, BAO Hui-Ling. The comparison of clinical features in children with different control levels of asthma[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(2): 138-143 https://doi.org/10.7499/j.issn.1008-8830.2015.02.006

References

[1] Letitre SL, de Groot EP, Draaisma E, et al. Anxiety, depression and self-esteem in children with well-controlled asthma: case-control study[J]. Arch Dis Child, 2014, 99(8): 744-748.
[2] 中华医学会儿科学分会呼吸学组, 《中华儿科杂志》编辑委员会. 儿童支气管哮喘诊断与防治指南[J]. 中华儿科杂志, 2008, 46(10): 745-753.
[3] Zahran HS, Bailey CM, Qin X, et al. Assessing asthma severity among children and adults with current asthma[J]. J Asthma, 2014, 51(6): 610-617.
[4] 全国儿科哮喘协作组, 中国疾病预防控制中心环境与健康相关产品安全所. 第三次中国城市儿童哮喘流行病学调查[J]. 中华儿科杂志, 2013, 51(10): 729-735.
[5] Olenec JP, Kim WK, Lee WM, et al. Weekly monitoring of children with asthma for infections and illness during common cold seasons[J]. J Allergy Clin Immunol, 2010, 125(5): 1001-1006.
[6] Bizzintino J, Lee WM, Laing IA, et al. Association between human rhinovirus C and severity of acute asthma in children[J]. Eur Respir J, 2011, 37(5): 1037-1042.
[7] Fuchs O, von Mutius E. Prenatal and childhood infections: implications for the development and treatment of childhood asthma[J]. Lancet Respir Med, 2013, 1(9): 743-754.
[8] Kloepfer KM, Olenec JP, Lee WM, et al. Increased H1N1 infection rate in children with asthma[J]. Am J Respir Crit Care Med, 2012, 185(12): 1275-1279.
[9] Corne JM, Marshall C, Smith S, et al. Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study[J]. Lancet, 2002, 359(9309): 831-834.
[10] Mackenzie KJ, Anderton SM, Schwarze J. Viral respiratory tract infections and asthma in early life: cause and effect? [J]. Clin Exp Allergy, 2014, 44(1): 9-19.
[11] Stein RT, Martinez FD. Respiratory syncytial virus and asthma: still no final answer[J]. Thorax, 2010, 65(12): 1033-1034.
[12] Ciprandi G, Schiavetti I, Bellezza Fontana R, et al. Overweight and obesity as risk factors for impaired lung function in patients with asthma: a real-life experience[J]. Allergy Asthma Proc, 2014, 35(4): e62-e71.
[13] 中国哮喘儿童家长知信行调查项目组. 中国大陆29个城市哮喘患儿病情控制状况及影响因素[J]. 中华儿科杂志, 2013, 51(2): 90-95.
[14] Sonomjamts M, Dashdemberel S, Logii N, et al. Prevalence of asthma and allergic rhinitis among adult population in Ulaanbaatar, Mongolia[J]. Asia Pac Allergy, 2014, 4(1): 25-31.
[15] Yilmaz O, Bakirtas A, Ertoy Karagol HI, et al. Allergic rhinitis may impact the recovery of pulmonary function tests after moderate/severe asthma exacerbation in children[J]. Allergy, 2014, 69(5): 652-657.
[16] 熊梅, 倪陈, 潘家华, 等. 合肥市儿童哮喘的危险因素分析[J]. 中国当代儿科杂志, 2013, 15(5): 364-367.
[17] Esteban CA, Klein RB, Kopel SJ, et al. Underdiagnosed and undertreated allergic rhinitis in urban school-aged children with asthma[J]. Pediatr Allergy Immunol Pulmonol, 2014, 27(2): 75-81.
[18] Shen CY, Lin MC, Lin HK, et al. The natural course of eczema from birth to age 7 years and the association with asthma and allergic rhinitis: a population-based birth cohort study[J]. Allergy Asthma Proc, 2013, 34(1): 78-83.
[19] Cho YM, Ryu SH, Choi MS, et al. Asthma and allergic diseases in preschool children in Korea: findings from the pilot study of the Korean Surveillance System for Childhood Asthma[J]. Asthma, 2014, 51(4): 373-379.