Utility of fractional exhaled nitric oxide in children with asthma

AN Shu-Hua; TIAN Wen-Qiu; LI Jin-Ying

doi:10.7499/j.issn.1008-8830.2015.02.005

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Chinese Journal of Contemporary Pediatrics ›› 2015, Vol. 17 ›› Issue (2) : 134-137. DOI: 10.7499/j.issn.1008-8830.2015.02.005

CLINICAL RESEARCH

Utility of fractional exhaled nitric oxide in children with asthma

AN Shu-Hua, TIAN Wen-Qiu, LI Jin-Ying

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Abstract

Objective To study the utility of fractional exhaled nitric oxide (FeNO) in young children at different stages of asthma. Methods Fifty-eight children with newly diagnosed asthma (aged 1-3 years) at the acute exacerbation stage between April and June, 2014 were recruited. After 3 months' treatment, the children switched into the chronic persistent stage (n=34) or remission stage (n=24). Thirty aged-matched healthy children served as controls. FeNO levels and lung function were measured for all subjects. The best cut-off value of FeNO for the diagnosis of asthma was evaluated by receiver operating characteristic (ROC) curve. Results The FeNO levels in children with asthma at various stages were higher than controls (P<0.05). The FeNO levels in the acute exacerbation stage were highest, followed by the chronic persistent stage (P<0.05). FeNO level was correlated to the stages of asthma (r=-0.382, P<0.001). The cut-off value of FeNO for the diagnosis of asthma was 22.75 ppb by ROC curve, with the sensitivity of 0.933 and the specificity of 0.388. Conclusions The children with asthma at different stages have different FeNO levels. Measurement of FeNO is useful in the diagnosis of asthma in young children.

Key words

Asthma / Fraction exhaled nitric oxide / Child

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AN Shu-Hua, TIAN Wen-Qiu, LI Jin-Ying. Utility of fractional exhaled nitric oxide in children with asthma[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(2): 134-137 https://doi.org/10.7499/j.issn.1008-8830.2015.02.005

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