Clinical and imaging features of premature infants with different degrees of bronchopulmonary dysplasia

REN Yan-Li; KONG Xiang-Yong; DU Zhi-Fang; FENG Zhi-Chun; HUANG Jun-Jin; CHEN Jia; ZHANG Shan

doi:10.7499/j.issn.1008-8830.2015.05.005

PDF(1467 KB)

Chinese Journal of Contemporary Pediatrics ›› 2015, Vol. 17 ›› Issue (5) : 440-444. DOI: 10.7499/j.issn.1008-8830.2015.05.005

CLINICAL RESEARCH

Clinical and imaging features of premature infants with different degrees of bronchopulmonary dysplasia

REN Yan-Li^1,2, KONG Xiang-Yong¹, DU Zhi-Fang³, FENG Zhi-Chun¹, HUANG Jun-Jin¹, CHEN Jia¹, ZHANG Shan¹

Author information +

History +

Abstract

Objective To study the clinical and imaging features of premature infants with different degrees of bronchopulmonary dysplasia (BPD). Methods A prospective study was performed on the clinical data of 59 premature infants (gestational age <32 weeks) with BPD. Among the 59 premature infants, 37 cases had mild BPD and the other 22 cases had moderate to severe BPD. The clinical and imaging data were compared between these premature infants with different degrees of BPD. Results The durations of mechanical ventilation, oxygen therapy, antibiotic therapy, parenteral nutrition, and hospitalization in the moderate to severe group were significantly longer than those in the mild group (P<0.05). The incidence of nosocomial infection and number of times of red blood cell transfusion in the moderate to severe group were significantly higher than that in the mild group. The rates of X-ray changes, including grade I respiratory distress syndrome (1 day after birth) and hypolucency of lungs (4-10 days and ≥28 days after birth) were significantly higher in the mild group than in the moderate to severe group. The rates of X-ray changes in classical BPD stage III (4-10 days after birth) and IV (≥28 days after birth) were significantly higher in the moderate to severe group than in the mild group. Conclusions The durations of mechanical ventilation, oxygen therapy, and antibiotic therapy and the incidence of nosocomial infection are correlated with the severity of BPD. The premature infants with severer BPD need a longer duration of parenteral nutrition and more times of red blood cell transfusion and have more typical imaging changes of BPD. Imaging examination has a predictive value for the severity of BPD.

Key words

Bronchopulmonary dysplasia / Chest X-ray / Chest CT scan / Neonate

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

REN Yan-Li, KONG Xiang-Yong, DU Zhi-Fang, FENG Zhi-Chun, HUANG Jun-Jin, CHEN Jia, ZHANG Shan. Clinical and imaging features of premature infants with different degrees of bronchopulmonary dysplasia[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(5): 440-444 https://doi.org/10.7499/j.issn.1008-8830.2015.05.005

References

[1] Aly H. Is there a strategy for preventing bronchopulmonary dysplasia? Absence of evidence is not evidence of absence[J]. Pediatrics, 2007, 119(4): 818-820.
[2] Natarajan G, Pappas A, Shankaran S, et al. Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definition[J]. Early Hum Dev, 2012, 88(7): 509-515.
[3] Groothuis JR, Makari D. Defnition and outpatient management of the very low-birth-weight infant with bronchopulmonary dysplasia[J]. Adv Ther, 2012, 29(4): 297-3l1.
[4] Bhandari A, Bhandari V. Pitfalls, problems, and progress in bronchopulmonary dysplasia[J]. Pediatrics, 2009, 123(6): 1562-1573.
[5] Northway WH, Rosan RC, Porter DY. Pulmonary disease following respirator therapy of hyaline-membrane disease: bronchopulmonary dysphasia[J]. N Engl J Med, 1967, 276(7): 357-368.
[6] 邵肖梅, 叶鸿瑁, 丘小汕. 实用新生儿学 [M].第4版. 北京: 人民卫生出版社, 2011: 395-398.
[7] Mahut B, De Blic J, Emond S, et al. Chest computed tomography findings in bronchopulmonary dysplasia and correlation with lung function[J]. Arch Dis Child Fetal Neonatal Ed, 2007, 92(6): F459-F464.
[8] 李燕, 韦秋芬, 潘新年, 等. 早产儿支气管肺发育不良严重程度的影响因素[J].中国当代儿科杂志, 2014, 16(10): 1014-1018.
[9] 早产儿支气管发育不良调查协作组. 早产儿支气管肺发育不良发生率及高危因素的多中心回顾调查分析[J]. 中华儿科杂志, 2011, 49(9): 655-662.
[10] 王丽华, 宋庆花, 刘英慧, 等.支气管肺发育不良的 X 线与多层螺旋 CT 影像分析[J]. 中华肺部疾病杂志(电子版), 2014, 7(4): 427-429.
[11] Rossi UG, Owens CM. The radiology of chronic lung disease in children[J]. Arch Dis Child, 2005, 90(6): 601-607.
[12] Shin SM, Kim WS, Cheon JE, et al. Bronchopulmonary dysplasia: new high resolution computed tomography scoring system and correlation between the high resolution computed tomography score and clinical severity[J]. Korean J Radiol, 2013, 14(2): 350-360.
[13] Głowacka E, Lis G. Bronchopulmonary dysplasia - early and long-term pulmonary sequelae[J]. Pneumonol Alergol Pol, 2008, 76(6): 437-445.