Correlation between growth rate of corpus callosum and neuromotor development in preterm infants

LIU Rui-Ke; SUN Jie; HU Li-Yan; LIU Fang

doi:10.7499/j.issn.1008-8830.2015.08.016

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Chinese Journal of Contemporary Pediatrics ›› 2015, Vol. 17 ›› Issue (8) : 841-846. DOI: 10.7499/j.issn.1008-8830.2015.08.016

CLINICAL RESEARCH

Correlation between growth rate of corpus callosum and neuromotor development in preterm infants

LIU Rui-Ke¹, SUN Jie², HU Li-Yan³, LIU Fang⁴

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Abstract

Objective To investigate the growth rate of corpus callosum by cranial ultrasound in very low birth weight preterm infants and to provide a reference for early evaluation and improvement of brain development. Methods A total of 120 preterm infants under 33 weeks' gestation were recruited and divided into 26-29⁺⁶ weeks group (n=64) and 30-32⁺⁶ weeks group (n=56) according to the gestational age. The growth rate of corpus callosum was compared between the two groups. The correlation between the corpus callosum length and the cerebellar vermis length and the relationship of the growth rate of corpus callosum with clinical factors and the neuromotor development were analyzed. Results The growth rate of corpus callosum in preterm infants declined since 2 weeks after birth. Compared with the 30-32⁺⁶ weeks group, the 26-29⁺⁶ weeks group had a significantly lower growth rate of corpus callosum at 3-4 weeks after birth, at 5-6 weeks after birth, and from 7 weeks after birth to 40 weeks of corrected gestational age. There was a positive linear correlation between the corpus callosum length and the cerebellar vermis length. Small-for-gestational age infants had a low growth rate of corpus callosum at 2 weeks after birth. The 12 preterm infants with severe abnormal intellectual development had a lower growth rate of corpus callosum compared with the 108 preterm infants with non-severe abnormal intellectual development at 3-6 weeks after birth. The 5 preterm infants with severe abnormal motor development had a significantly lower growth rate of corpus callosum compared with the 115 preterm infants with non-severe abnormal motor development at 3-6 weeks after birth. Conclusions The decline of growth rate of corpus callosum in preterm infants at 2-6 weeks after birth can increase the risk of severe abnormal neuromotor development.

Key words

Corpus callosum / Brain / Gestational age / Preterm infant

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LIU Rui-Ke, SUN Jie, HU Li-Yan, LIU Fang. Correlation between growth rate of corpus callosum and neuromotor development in preterm infants[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(8): 841-846 https://doi.org/10.7499/j.issn.1008-8830.2015.08.016

References

[1] 李薇, 黄燕, 叶如霞, 等. 早产儿的早期干预对智力、运动发育及脑瘫发生率的影响[J]. 中国妇幼保健, 2011, 22(26): 3411-3413.
[2] Perenyi A, Amodio J, Katz JS, et al. Clinical utility of corpus callosum measurements in head sonograms of preterm infants: a cohort study[J]. BMJ open, 2013, 3(4): e002499.
[3] Anderson NG, Laurent I, Woodward IJ, et al. Detection of impaired growth of the corpus callosum in premature infants[J]. Pediatrics, 2006, 118(3): 951-960.
[4] 刘芳, 刘皎然, 杜志方, 等. 早产儿胼胝体生长率与运动发育迟滞关系的研究[J]. 中国当代儿科杂志, 2008, 10(6): 701-704.
[5] 范存仁. CDCC婴幼儿智能发育测查手册[M]. 北京: 团结出版社, 1988: 9.
[6] 邵肖梅, 叶鸿瑁, 丘小灿. 实用新生儿学[M]. 第4版. 北京：人民卫生出版社, 2011: 675.
[7] Gooijers J, Swinnen SP. Interactions between brain structure and behavior: the corpus callosum and bimanualcoordination[J]. Neurosci Biobehav Rev, 2014, 43(6): 1-19.
[8] Thompson DK, Inder TE, Faggian N, et al. Characterization of the corpus callosum in very preterm and full-term infants utilizing MRI[J]. Neuroimage, 2011, 55(2): 479-490.
[9] Amaniti EM, Hasenpusch-Theil K, Li Z, et al. Gli3 is required in Emx1+ progenitors for the development of the corpus callosum[J]. Dev Biol, 2013, 376(2): 113-124.
[10] 刘瑞可, 刘芳, 李建英, 等. 早产儿与足月儿胼胝体面积的对比研究[J]. 中国当代儿科杂志, 2014, 16(5): 478-482.
[11] 刘皎然, 刘芳, 王菲, 等. 早产儿胼胝体生长率与神经运动发育关系的超声研究[J]. 临床超声医学杂志, 2009, 11(3): 165-167.
[12] 胡原, 陈文娟, 张号绒, 等. 早产儿胼胝体发育的超声监测[J]. 医学影像杂志, 2010, 20(7): 1038-1041.
[13] 胡原, 陈文娟, 何静波, 等. 新生儿胼胝体发育不全的超声诊断[J]. 中国医学影像杂志, 2010, 18(6): 569-572.
[14] Groenendaal F, Lammers H, Smit D, et al. Nitrotyrosine in brain tissue of neonates after perinatal asphyxia[J]. Arch Dis Child Fetal Neonatal Ed, 2006, 91(6): F429-F433.
[15] Zayek MM, Benjamin JT, Maertens P, et al. Cerebellar hemorrhage: a major morbidity in extremely preterm infants[J]. J Perinatol, 2012, 32(9): 699-704.
[16] Limperopoulos C, Soul JS, Haidar H, et al. Impaired trophic interactions between the cerebellum and the cerebrum among preterm infants[J]. Pediatrics, 2005, 116(4): 844-850.
[17] Bodensteiner JB, Johnsen SD. Cerebellar injury in the extremely premature infant: newly recognized but relatively common outcome[J]. J Child Neurol, 2005, 20(2): 139-142.
[18] Graca AM, Geraldo AF, Cardoso K, et al. Preterm cerebellum at term age: ultrasound measurements are not different from infants born at term[J]. Pediatr Res, 2013, 74(6): 698-704.