Effects of hemoperfusion treatment on serum IL-23 and IL-17 levels in children with Henoch-Sch&ouml;nlein purpure

LIU Li; HUANG Yan-Ping; FANG Xia-Ling; ZHANG Yuan-Yuan; CHEN Ning; HOU Hong-Hong

doi:10.7499/j.issn.1008-8830.2015.08.007

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Chinese Journal of Contemporary Pediatrics ›› 2015, Vol. 17 ›› Issue (8) : 796-799. DOI: 10.7499/j.issn.1008-8830.2015.08.007

CLINICAL RESEARCH

Effects of hemoperfusion treatment on serum IL-23 and IL-17 levels in children with Henoch-Schönlein purpure

LIU Li, HUANG Yan-Ping, FANG Xia-Ling, ZHANG Yuan-Yuan, CHEN Ning, HOU Hong-Hong

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Abstract

Objective To study the effects of hemoperfusion treatment on serum interleukin-17 (IL-17) and IL-23 levels in children with Henoch-Schönlein purpura (HSP). Methods Eighty-seven children who were diagnosed with HSP and who had received hemoperfusion treatment between January 2011 and December 2012 were enrolled. Twenty-seven sex- and age-matched healthy children were recruited as normal controls. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum concentrations of IL-17 and IL-23. Results The serum IL-23 and IL-17 levels in the HSP group were significantly higher than in the control group (P< 0.05). After hemoperfusion treatment, the serum IL-23 and IL-17 levels in the HSP group were significantly reduced to the levels of the control group. Serum serum IL-17 level was positively correlated with serum IL-23 level (P< 0.05) in children with HSP. Conclusions Hemoperfusion treatment can reduce serum IL-23 and IL-17 levels in children with HSP, suggesting that the treatment may be effective for HSP.

Key words

Henoch-Schö / nlein Purpura / Interleukin-23 / Interleukin-17 / Hemoperfusion / Child

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LIU Li, HUANG Yan-Ping, FANG Xia-Ling, ZHANG Yuan-Yuan, CHEN Ning, HOU Hong-Hong. Effects of hemoperfusion treatment on serum IL-23 and IL-17 levels in children with Henoch-Schönlein purpure[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(8): 796-799 https://doi.org/10.7499/j.issn.1008-8830.2015.08.007

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