Clinical features, prevention and treatment of respiratory distress syndrome in neonates of different gestational ages in tertiary hospitals in Northwest China

FU Hui-Ling, LIU Li, ZHANG Juan, WANG Quan-Li

Chinese Journal of Contemporary Pediatrics ›› 2015, Vol. 17 ›› Issue (10) : 1039-1044.

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Chinese Journal of Contemporary Pediatrics ›› 2015, Vol. 17 ›› Issue (10) : 1039-1044. DOI: 10.7499/j.issn.1008-8830.2015.10.004
CLINICAL RESEARCH

Clinical features, prevention and treatment of respiratory distress syndrome in neonates of different gestational ages in tertiary hospitals in Northwest China

  • FU Hui-Ling1,2, LIU Li1, ZHANG Juan3, WANG Quan-Li4
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Abstract

Objective To investigate the clinical features, prevention and treatment of respiratory distress syndrome (RDS) in neonates of different gestational ages (GA) in the tertiary hospitals in Northwest China. Methods A total of 440 neonates diagnosed with RDS between January and December, 2011 in 12 tertiary hospitals in Northwest China were enrolled and classified into three groups:early preterm (GA<34 weeks;n=247), late preterm (GA 34-36+6 weeks;n=131) and full-term (GA≥37 weeks;n=62). The clinical data, including perinatal factors, prevention and treatment, complications and prognosis, were comparatively analyzed among the three groups. Results The rate of multiple births in the early preterm group was higher than the other two groups. The two preterm groups showed a higher incidence of premature rupture of membranes than the full-term group. The full-term group had a higher rate of cesarean section without contractions than the two preterm groups. The early preterm group had the highest application rate of antenatal steroids. Compared with the other two groups, the early preterm group had a higher application rate of pulmonary surfactants (PS) and an earlier time of first application of PS. The full-term group had a lower resuscitation rate than the two preterm groups. The early preterm group showed a higher incidence of patent ductus arteriosus and intracranial hemorrhage than the other two groups. The cure rate of RDS (78.2%) was the highest in the full-term group, followed by the late preterm group (58.6%) and the early preterm group (42.9%). Conclusions RDS infants of different GA in Northwest China have significant differences in perinatal factors, antenatal prevention, PS treatment, complications and prognosis.

Key words

Respiratory distress syndrome / Gestational age / Treatment / Neonate

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FU Hui-Ling, LIU Li, ZHANG Juan, WANG Quan-Li. Clinical features, prevention and treatment of respiratory distress syndrome in neonates of different gestational ages in tertiary hospitals in Northwest China[J]. Chinese Journal of Contemporary Pediatrics. 2015, 17(10): 1039-1044 https://doi.org/10.7499/j.issn.1008-8830.2015.10.004

References

[1] Reese HC. The epidemiology of respiratory failurein neonates bomatan estimated gestational age of 34 weeks or more[J]. J Perinatol, 2005, 25(4):251-257.
[2] 新生儿呼吸疾病协作组. 国内部分地区新生儿重症监护病房新生儿呼吸窘迫综合征诊治现状及东西部差异调查[J]. 中华围产医学杂志, 2009, 12(2):121-126.
[3] 王卫平, 毛萌, 李廷玉, 等. 儿科学[M]. 第8 版. 北京:人民卫生出版社, 2013:115-118.
[4] Lumbiganon P, Laopaiboon M, Gtilmezoglu AM, et al. Method of delivery and pregnancy outcomes in Asia:the WHO global survey on maternal and perinatal health 2007-2008[J]. Lancet, 2010, 375(9713):490-499.
[5] 侯磊, 李光辉, 周丽颖, 等. 全国剖宫产率及剖宫产构成比调查的多中心研究[J]. 中华妇产科杂志, 2014, 49(10):728-735.
[6] Sweet DG, Camielli V, Greisen G, et al. European consensus guidelines on the management of neonatal respiratorydistress syndrome in preterm infants 2013 update[J]. Neonatology, 2013, 103(4):353-368.
[7] Horbar JD, Badger GJ, Carpenter JH, et al. Trends in mortality and morbidity for very low birth weight infants, 1991-1999[J]. Pediatrics, 2002, 110(1 Pt 1):143-151.
[8] Curstedt T, Johansson J. New synthetic surfactants basic science[J]. Biolneonate, 2005, 87(4):332-337.
[9] Soll R, Ozek E. Prophylactic protein free synthetic surfactant for preventing morbidity and mortality in preterminfants[J]. Cochrane Database Syst Rev, 2010, 20(1):CD001079.
[10] 田青, 吴本清, 刘晓红. 深圳地区新生儿呼吸窘迫综合征流行病学调查[J]. 中华实用儿科临床杂志, 2013, 28(34):1083-1085.
[11] 刘俐. 外源性肺泡表面活性物质应用研究和发展趋势[J]. 发育医学电子杂志, 2014, 2(1):43-48.
[12] Rojas MA, Lozano JM, Rojas MX, et al. Very early surfactant without mandatory ventilation in premature infants treated with early continuous positive airway pressure:a randomized, controlled trial[J]. Pediatrics, 2009, 123(1):137-142.
[13] Stevens TP, Harrington EW, Blennow M, et al. Early surfactant administration with brief ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome[J]. Cochrane Database Syst Rev, 2007, (4):CD003063.
[14] Aly H, Hammad TA, Essers J, et al. Is mechanical ventilation associated with intraventricular hemorrhage in preterm infants[J]. Brain Dev, 2012, 34(3):201-205.
[15] Lee JY, Kim HS, Jung E, et al. Risk factors for periventricularintraventricular hemorrhage in prematureinfants[J]. J Korean Med Sci, 2010, 25(3):418-424.
[16] Nemerofsky SL, Parravicini E, Bateman D, et al. The ductus arteriosus rarely requires treatment in infants>1000 grams[J]. Am J Perinatol, 2008, 25(10):661-666.
[17] 方文君, 杨长仪, 陈涵强. 早产儿动脉导管未闭研究进展[J]. 中国新生儿科杂志, 2013, 28(3):203-206.
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