Resveratrol increases sirtuin 1 expression in peripheral blood mononuclear cells of premature infants and inhibits the oxidative stress induced by hyperoxia in vivo
YANG Xi, DONG Wen-Bin, LI Qing-Ping, KANG Lan, LEI Xiao-Ping, ZHANG Lian-Yu, LU You-Ying, ZHAI Xue-Song
Department of Neonatology, First Affiliated Hospital of Sichuan Medical University, Luzhou, Sichuan 646000, China
Abstract Objective To explore the effect of resveratrol on the levels of sirtuin 1 (SIRT1) and reactive oxygen species (ROS) in peripheral blood mononuclear cells (PBMCs) of premature infants exposed to hyperoxia. Methods Peripheral blood and isolated PBMCs from premature infants (gestational age Results Compared with the control group, the level of SIRT1 in the air+resveratrol group increased significantly (PPPPConclusions Resveratrol can increase SIRT1 expression in PBMCs and inhibit SIRT1 shuttle from nucleus to cytoplasm in order to increase the ability of antioxidative stress in premature infants exposed to hyperoxia, thereby reducing the oxidative stress injury in premature infants.
YANG Xi,DONG Wen-Bin,LI Qing-Ping et al. Resveratrol increases sirtuin 1 expression in peripheral blood mononuclear cells of premature infants and inhibits the oxidative stress induced by hyperoxia in vivo[J]. CJCP, 2016, 18(1): 72-77.
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