Abstract Objective To investigate the effect of continuous veno-venous hemofiltration (CVVH) on inflammatory mediators in children with severe hand, foot and mouth disease (HFMD), and to investigate its clinical efficacy. Methods A total of 36 children with stage IV HFMD were enrolled and randomly divided into conventional treatment group and CVVH group (n=18 each). The children in the CVVH group were given CVVH for 48 hours in addition to the conventional treatment. The levels of interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α) and lactic acid in peripheral venous blood, heart rate, blood pressure, and left ventricular ejection fraction were measured before treatment and after 24 and 48 hours of treatment. Results After 24 hours of treatment, the conventional treatment group had a significantly reduced serum IL-2 level (PPPPPConclusions CVVH can effectively eliminate inflammatory factors, reduce heart rate and venous blood lactic acid, and improve heart function in children with severe HFMD.
CAO Li-Jing,GENG Wen-Jin,XU Mei-Xian et al. Effect of continuous hemofiltration on inflammatory mediators and hemodynamics in children with severe hand, foot and mouth disease[J]. CJCP, 2016, 18(3): 219-223.
CAO Li-Jing,GENG Wen-Jin,XU Mei-Xian et al. Effect of continuous hemofiltration on inflammatory mediators and hemodynamics in children with severe hand, foot and mouth disease[J]. CJCP, 2016, 18(3): 219-223.
Chen SC, Chang HL, Yan TR, et al. An eight-year study of epidemiologic features of enterovirus 71 infection in Taiwan[J]. Am J Trop Med Hyg, 2007, 77(1): 188-191.
Tisoncik JR, Korth MJ, Simmons CP, et al. Into the eye of the cytokine storm[J]. Microbiol Mol Biol Rev, 2012, 76(1): 16-32.
[12]
Lin TY, Hsia SH, Huang YC, et al. Proinflammatory cytokine reactions in enterovirus 71 infections of the central nervous system[J]. Clin Infect Dis, 2003, 36(3): 269-274.
