Changes in ambulatory electrocardiographic findings after oral administration of low-dose propranolol in infants with hemangioma
YI Lan-Fen1, WEN Hong-Xia1, HUANG Sui2, QIU Mei1, ZHANG Jing-Yang1, CAO Xiao-Xiao1
Department of Electrocardiogram, Wuhan Medical Health Care Center for Women and Children/Wuhan Children's Hospital/Wuhan Maternal and Child Health Care Hospital, Wuhan 430016, China
Abstract Objective To investigate the effects of oral administration of low-dose propranolol on heart rate variability (HRV), acceleration capacity (AC), deceleration capacity (DC), and cardiac conduction in the treatment of infantile hemangioma. Methods A total of 118 infants with hemangioma (≤1 year) were enrolled, and 24-hour ambulatory electrocardiography was performed before oral administration of low-dose propranolol and after one month of administration. The changes in time-domain indices [standard deviation of all normal sinus RR intervals (SDNN), standard deviation of all mean 5-minute RR intervals (SDANN), root mean squared successive difference (RMSSD), and percentage of successive normal sinus RR intervals >50 ms (PNN50)] and frequency-domain indices [low frequency (LF) and high frequency (HF)] for HRV, AC, and DC were observed, as well as abnormalities in cardiac conduction and other aspects after administration of propranolol. Results After administration of propranolol, the infants had significantly increased SDNN, RMSSD, LF, HF, and PNN50 (PPConclusions In the treatment of infantile hemangioma, propranolol can inhibit the activity of sympathetic nerve and block cardiac conduction, but without any serious adverse effect.
YI Lan-Fen,WEN Hong-Xia,HUANG Sui et al. Changes in ambulatory electrocardiographic findings after oral administration of low-dose propranolol in infants with hemangioma[J]. CJCP, 2016, 18(4): 345-349.
YI Lan-Fen,WEN Hong-Xia,HUANG Sui et al. Changes in ambulatory electrocardiographic findings after oral administration of low-dose propranolol in infants with hemangioma[J]. CJCP, 2016, 18(4): 345-349.
Shah S, Frieden IJ. Treatment of infantile hemangiomas with beta-blockers: a review[J]. Skin Therapy Lett, 2013, 18(6): 5-7.
[3]
Marqueling AL, Oza V, Frieden IJ, et al. Propranolol and infantile hemangiomas four years later: a systematic review[J]. Pediatr Dermatol, 2013, 30(2): 182-191.
Zhou HH, Koshakji RP, Silberstein DJ, et al. Altered sensitivity to and clearance of propranolol in men of Chinese descent as compared with American whites[J]. N Engl J Med, 1989, 320(9): 565-570.
