Research advances in association between pediatric obesity and bronchial asthma

ZHU Lian; XU Zhi-Liang; CHENG Yan-Yang

doi:10.7499/j.issn.1008-8830.2016.07.020

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Chinese Journal of Contemporary Pediatrics ›› 2016, Vol. 18 ›› Issue (7) : 671-676. DOI: 10.7499/j.issn.1008-8830.2016.07.020

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Research advances in association between pediatric obesity and bronchial asthma

ZHU Lian^1,2, XU Zhi-Liang¹, CHENG Yan-Yang¹

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Abstract

This review article introduces the research advances in the pathophysiological mechanism of obesity in inducing pediatric bronchial asthma, including the role of leptin in obesity and asthma, the association of plasminogen activator inhibitor-1 with obesity and asthma, the association of adiponectin and interleukins with obesity and asthma, and the influence of neurotransmitter on asthma. In particular, this article introduces the latest research on the inhibition of allergic asthma through targeting at the nociceptor of dorsal root ganglion and blocking the signaling pathway of the nociceptor.

Key words

Obesity / Bronchial asthma / Dorsal root ganglion / Nociceptor / Child

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ZHU Lian, XU Zhi-Liang, CHENG Yan-Yang. Research advances in association between pediatric obesity and bronchial asthma[J]. Chinese Journal of Contemporary Pediatrics. 2016, 18(7): 671-676 https://doi.org/10.7499/j.issn.1008-8830.2016.07.020

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