[1] 陈芳芳, 米杰. 儿童肥胖的评价标准及流行现状[J]. 实用儿科临床杂志, 2007, 22(23): 1837-1840.
[2] 聂晓娟. 儿童青少年超重肥胖现状及成因研究[J]. 中国保健营养, 2013, 23(5): 568-570.
[3] 全国儿科哮喘协作组;中国疾病预防控制中心环境与健康相关产品安全所. 第三次中国城市儿童哮喘流行病学调查[J]. 中华儿科杂志, 2013, 51(10): 729-735.
[4] Chen ZH, Wang PL, Shen HH. Asthma research in China: a fiveyear review[J]. Respirology, 2013, 18 (Suppl 3): 10-19.
[5] 刘传合, 洪建国, 尚云晓, 等. 中国16 城市儿童哮喘患病率 20 年对比研究[J]. 中国实用儿科杂志, 2015, 30(8): 596-600.
[6] Delgado J, Barranco P, Quirce S. Obesity and asthma[J]. J Investig Allergol Clin Immunol, 2008, 18(6): 420-425.
[7] Centers for Disease Control and Prevention. Asthma Surveillance Data[EB/OL]. [February 1st , 2016]. http://www.cdc.gov/asthma/ asthmadata.htm.
[8] 世界卫生组织( 慢性呼吸道疾病中心). 哮喘的影响范围[EB/ OL]. [2016-01-02]. http://www.who.int/respiratory/asthma/scope/ zh/.
[9] Baruwa P, Sarmah KR. Obesity and asthma[J]. Lung India, 2013, 30(1): 38-46.
[10] Johnston RA, Zhu M, Rivera-Sanchez YM, et al. Allergic airway responses in obese mice[J]. Am J Respir Crit Care Med, 2007, 176(7): 650-658.
[11] 卢洪华, 李艳春, 华树成. 支气管哮喘临床蛋白质组学研究进展[J]. 中国实验诊断学, 2013, 17(7): 1352-1354.
[12] Shore SA, Fredberg JJ. Obesity, smooth muscle, and airway hyperresponsiveness[J]. J Allergy Clin Immunol, 2005, 115(5): 925-927.
[13] 谢海玲, 彭佳丽, 张觉昂, 等. 机动车尾气对大鼠气道高反应性的影响 [J]. 湖南师范大学学报 ( 医学版), 2015, 12(2): 10-13.
[14] Hobgood DK. Personality and illness: genetic connections?[J]. Med Hypotheses, 2011, 76(1): 89-93.
[15] Dandona P, Ghanim H, Monte SV, et al. Increase in the mediators of asthma in obesity and obesity with type 2 diabetes: reduction with weight loss[J]. Obesity (Silver Spring), 2014, 22(2): 356- 362.
[16] Leite N, Lazarotto L, Milano GE, et al. Beta 2-adrenergic receptor gene association with overweight and asthma in children and adolescents and its relationship with physical fitness[J]. Rev Paul Pediatr, 2015, 33(4): 381-386.
[17] Yang YH, Liu YQ, Zhang L. Genetic polymorphisms of the TNF- α-308G/A are associated with metabolic syndrome in asthmatic patients from Hebei province, China[J]. Int J Clin Exp Pathol, 2015, 8(10): 13739-13746.
[18] Beuther DA, Weiss ST, Sutherland ER. Obesity and asthma[J]. Am J Respir Crit Care Med, 2006, 174(2): 112-119.
[19] Talbot S, Abdulnour RE, Burkett PR, et al. Silencing nociceptor neurons reduces allergic airway inflammation[J]. Neuron, 2015, 87(2): 341-354.
[20] Hox V, Vanoirbeek JA, Alpizar YA, et al. Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice[J]. Am J Respir Crit Care Med, 2013, 187(5): 486-493.
[21] Baraniuk JN. Rise of the sensors: nociception and pruritus[J]. Curr Allergy Asthma Rep, 2012, 12(2): 104-114.
[22] Torday JS, Rehan VK. On the evolution of the pulmonary alveolar lipofibroblast[J]. Exp Cell Res, 2016, 340(2): 215-219.
[23] Emilio AS, Tiffany Z, Charles W, et al. Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma[J]. Cell Metab, 2013, 17(1): 35- 48.
[24] Sierra-Honigmann MR, Nath AK, Murakami C, et al. Biological action of leptin as an angiogenic factor[J]. Science, 1998, 281(5383): 1683-1686.
[25] Mai XM, Bottcher MF, Leijon I. Leptin and asthma in overweight children at 12 years of age[J]. Pediatr Allergy Immunol, 2004, 15(6): 523-530.
[26] Qin L, Tan YR, Hu CP, et al. Leptin is oversecreted by respiratory syncytial virus-infected bronchial epithelial cells and regulates Th2 and Th17 cell differentiation[J]. Int Arch Allergy Immunol, 2015, 167(1): 65-71.
[27] 张超, 尚云晓, 魏兵, 等. 瘦素及其受体在哮喘BALB/c 小鼠肺组织中的表达及布地奈德的干预作用[J]. 中国当代儿科杂志, 2015, 17(6): 623-628.
[28] De Taeye B, Smith LH, Vaughan DE. Plasminogen activator inhibitor-1: a common denominator in obesity, diabetes and cardiovascular disease[J]. Curr Opin Pharmacol, 2005, 5(2): 149- 154.
[29] Bora E, Soylar R, Arıkan-Ayyıldız Z, et al. Plasminogen activator inhibitor-1 and angiotensin converting enzyme gene polymorphisms in Turkish asthmatic children[J]. Allergol Immunopathol (Madr), 2013, 41(1): 11-16.
[30] 蒙绪标, 符兰芳, 刘婷婷, 等. 2 型糖尿病患者血清PAI-1 表达与肥胖的相关性 [J]. 医学临床研究, 2015, 32(9): 53-55.
[31] Ma LJ, Mao SL, Taylor KL, et al. Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor-1[J]. Diabetes, 2004, 53(2): 336-346.
[32] Delgado J, Barranco P, Quirce S. Obesity and asthma[J]. J Investig Allergol Clin Immunol, 2008, 18(6): 420-425.
[33] Ballantyne D, Scott H, MacDonald-Wicks L, et al. Resistin is a predictor of asthma risk and resistin: adiponectin ratio is a negative predictor of lung function in asthma[J/OL]. Clin Exp Allergy, 2016 Apr 15. [Epub ahead of print].
[34] Sood A, Shore SA. Adiponectin, adiponectin, leptin, and resistin in asthma: basic mechanisms through population studies[J]. J Allergy (Cairo), 2013, 2013: 785835.
[35] Garcia P, Sood A. Adiponectin in pulmonary disease and critically ill patients[J]. Curr Med Chem, 2012, 19(32): 5493- 5500.
[36] Holguin F, Rojas M, Brown L, et al. Airway and plasma leptin and adiponectin in lean and obese asthmatics and controls[J]. J Asthma, 2011, 48(3): 217-223.
[37] Lee SJ, Lee EJ, Kim SK, et al. Identification of pro-inflammatory cytokines associated with muscle invasive bladder cancer; the roles of IL-5, IL-20, and IL-28A[J]. PLoS One, 2012, 7(9): e40267.
[38] Esnault S, Kelly EA, Johansson MW, et al. Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines[J]. Clin Immunol, 2014, 150(1): 90-100.
[39] Cho JY, Miller M, Baek KJ, et al. Inhibition of airway remodeling in IL-5-deficient mice[J]. J Clin Invest, 2004, 113(4): 551-560.
[40] Marijsse GS, Seys SF, Schelpe AS, et al. Obese Individuals with asthma preferentially have a high IL-5/IL-17A/IL-25 sputum inflammatory pattern[J]. Am J Respir Crit Care Med, 2014, 189(10): 1284-1285.
[41] Wu D, Molofsky AB, Liang HE, et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis[J]. Science, 2011, 332(6026): 243-247.
[42] Wensveen FM, Valentić S, Šestan M, et al. The "Big Bang" in obese fat: events initiating obesity-induced adipose tissue inflammation[J]. Eur J Immunol, 2015, 45(9): 2446-2456.
[43] Chen CL, Li X, Xing XH, et al. Effect of TRPV1 gene mutation on bronchial asthma in children before and after treatment[J]. Allergy Asthma Proc, 2015, 36(2): e29-e36.
[44] Manuyakorn W, Howarth PH, Holgate ST. Airway remodelling in asthma and novel therapy[J]. Asian Pac J Allergy Immunol, 2013, 31(1): 3-10.
[45] Bonini1 S, Lambiase A, Properzi F, et al. Nerve growth factor and asthma[J]. Allergy, 2002, 57(Suppl 72): 13-15.
[46] Quarcoo D, Schulte-Herbrüggen O, Lommatzsch M, et al. Nerve growth factor induces increased airway inflammation via a neuropeptide-dependent mechanism in a transgenic animal model of allergic airway inflammation[J]. Clin Exp Allergy, 2004, 34(7): 1146-1151.
[47] Olgart C, Glund H, Blay FD, et al. Nerve growth factor levels and localisation in human asthmatic Bronchi[J]. Eur Respir J, 2002, 20(5): 1110-1116.
[48] Aloe L, Rocco ML, Bianchi P, et al. Nerve growth factor: from the early discoveries to the potential clinical use[JL]. J Transl Med, 2012, 10: 239.
[49] Dinh QT, Groneberg DA, Peiser C, et al. Substance P expression in TRPV1 and trkA-positive dorsal root ganglion neurons innervating the mouse lung[J]. Respir Physiol Neurobiol, 2004, 144(1): 15-24.
[50] Nassenstein C, Dawbarn D, Pollock K, et al. Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma[J]. J Allergy Clin Immunol, 2006, 118(3): 597-605.
[51] Anand U, Otto WR, Casula MA, et al. The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons[J]. Neurosci Lett, 2006, 399(1-2): 51-56.
[52] Groth M, Helbig T, Grau V, et al. Spinal afferent neurons projecting to the rat lung and pleura express acid sensitive channels[J]. Respir Res, 2006, 7(1): 96-106.
[53] Tränkner D, Hahne N, Sugino K, et al. Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways[J]. Proc Natl Acad Sci U S A, 2014, 111(31): 11515- 11520.
[54] Zhu L, Oh JH, Zhu Y. Upregulation of nav1.7 through high salt loading[J]. J Neurogastroenterol Motil, 2014, 20(2): 273-275.
[55] Hox V, Vanoirbeek JA, Alpizar YA, et al. Crucial role of transient receptor potential ankyrin 1 and mast cells in induction of nonallergic airway hyperreactivity in mice[J]. Am J Respir Crit Care Med, 2013, 187(5): 486-493.
[56] Tränkner D, Hahne N, Sugino K. Population of sensory neurons essential for asthmatic hyperreactivity of inflamed airways[J]. Proc Natl Acad Sci U S A, 2014, 111(31): 11515-11520.
[57] Zhu L, Guan QW, Xu S, et al. Diet-induced obesity causes peripheral sensory nerves hypersensitivity in rats[J]. Gastroenterology, 2016, 150(4): 344.
[58] Zsombok A. Vanilloid receptors-do they have a role in whole body metabolism? Evidence from TRPV1[J]. J Diabetes Complications, 2013, 27(3): 287-292.