Lamotrigine monotherapy in children with epilepsy: a systematic review

LIU Yan-Tao; ZHANG Ling-Li; HUANG Liang; ZENG Li-Nan

doi:10.7499/j.issn.1008-8830.2016.07.003

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Chinese Journal of Contemporary Pediatrics ›› 2016, Vol. 18 ›› Issue (7) : 582-588. DOI: 10.7499/j.issn.1008-8830.2016.07.003

CLINICAL RESEARCH

Lamotrigine monotherapy in children with epilepsy: a systematic review

LIU Yan-Tao^1,2,3, ZHANG Ling-Li^1,2,3, HUANG Liang^1,2,3, ZENG Li-Nan^1,2,3

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Abstract

Objective To investigate the efficacy and safety of lamotrigine monotherapy in children with epilepsy via a systematic review. Methods PubMed, Cochrane, CNKI, VIP, CBM, Wanfang Data were searched for randomized controlled trials (RCTs) of lamotrigine monotherapy in children with epilepsy. Literature screening, data extraction, and quality assessment were performed according to the method recommended by Cochrane Collaboration. RevMan 5.2 software was used to conduct the Meta analysis. Results A total of 9 RCTs involving 1 016 participants were included. Lamotrigine yielded a significantly lower complete control rate of seizure than ethosuximide, but the complete control rate of seizure showed no significant differences between lamotrigine and carbamazepine/sodium valproate. Patients treated with lamotrigine had a significantly lower incidence rate of adverse events than those treated with carbamazepine, but the incidence rate of adverse events showed no significant differences between patients treated with lamotrigine and sodium valproate/carbamazepine. The drop-out rate showed no significant differences between the three treatment groups. Conclusions Lamotrigine is an ideal alternative drug for children who do not respond to traditional antiepileptic medication or experience significant adverse reactions; however, more high-quality RCTs with a large sample size and a long follow-up time are needed to confirm these conclusions.

Key words

Lamotrigine / Monotherapy / Epilepsy / Systematic review / Meta analysis / Child

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LIU Yan-Tao, ZHANG Ling-Li, HUANG Liang, ZENG Li-Nan. Lamotrigine monotherapy in children with epilepsy: a systematic review[J]. Chinese Journal of Contemporary Pediatrics. 2016, 18(7): 582-588 https://doi.org/10.7499/j.issn.1008-8830.2016.07.003

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