Distribution characteristics of Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila in hospitalized children with acute respiratory tract infection: an analysis of 13 198 cases
LIAO Jia-Yi, ZHANG Tao
Department of Respiration, Guangzhou Yuexiu District Children's Hospital, Guangzhou 510115, China
Abstract Objective To investigate the distribution characteristics of Mycoplasma pneumoniae (MP), Chlamydia pneumoniae (CP), and Legionella pneumophila (LP) in hospitalized children with acute respiratory tract infection (ARTI). Methods A total of 13 198 hospitalized children with ARTI were enrolled as study subjects. Whole blood and urine were collected. The passive agglutination was used to detect serum MP-IgM, ELISA was used to detect serum CP-IgM, and immunochromatography was performed to detect urinary LP antigen. Results Among the 13 198 hospitalized ARTI children, the detection rates of MP, CP, and LP were 25.31%, 12.74% and 3.27%, suggesting that MP had the highest detection rate (P<0.0125). The detection rates of MP in 2013 and 2014 were significantly higher than that in 2012 (P<0.0125). CP had the highest detection rate in 2013, and LP had the highest detection rate in 2014 (P<0.0125). These three pathogens were detected all around the year, and MP had the highest detection rate in all seasons (P<0.0125). The detection rate of mixed infection with three pathogens was 4.35%, and mixed infection with MP and CP was the most common (P<0.0071). Among the children in different age groups, the patients aged 5-16 years showed the highest overall detection rate of three pathogens (P<0.0071). Among the children with different types of ARTI, the children with bronchopneumonia showed the highest overall detection rate of three pathogens (P<0.0045). Conclusions MP, CP, and LP, particularly MP, are important pathogens for children with ARTI in the local area. LP infection tends to increase year by year and should be taken seriously in clinical practice.
LIAO Jia-Yi,ZHANG Tao. Distribution characteristics of Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila in hospitalized children with acute respiratory tract infection: an analysis of 13 198 cases[J]. CJCP, 2016, 18(7): 607-613.
LIAO Jia-Yi,ZHANG Tao. Distribution characteristics of Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila in hospitalized children with acute respiratory tract infection: an analysis of 13 198 cases[J]. CJCP, 2016, 18(7): 607-613.
Ngeow YF, Suwanjutha S, Chantarojanasriri T, et al. An Asian study on the prevalence of atypical respiratory pathogens in community-acquired pneumonia[J]. Int J Infect Dis, 2005, 9(3): 144-153.
[6]
Wu PS, Chang LY, Lin HC, et al. Epidemiology and clinical manifestations of children with macrolide-resistant Mycoplasma pneumoniae pneumonia in Taiwan[J]. Pediatr Pulmonol, 2013, 48(9): 904-911.
[7]
Liu WK, Liu Q, Chen de H, et al. Epidemiology of acute respiratory infections in children in Guangzhou: a three-year study[J]. PLoS One, 2014, 9(5): e96674.
Chen K, Jia R, Li L, et al. The aetiology of community associated pneumonia in children in Nanjing, China and aetiological patterns associated with age and season[J]. BMC Public Health, 2015, 15: 113.
Jain S, Williams DJ, Arnold SR, et al. Community-acquired pneumonia requiring hospitalization among U.S. children[J]. N Engl J Med, 2015, 372(9): 835-845.
[13]
Kurz H, Göpfrich H, Huber K, et al. Spectrum of pathogens of in-patient children and youths with community acquired pneumonia: a 3 year survey of a community hospital in Vienna, Austria[J]. Wien Klin Wochenschr, 2013, 125(21-22): 674-679.
[14]
Loens K, Ieven M. Mycoplasma pneumoniae: current knowledge on nucleic acid amplification techniques and serological diagnostics[J]. Front Microbiol, 2016, 7: 448.
[15]
Chiu CY, Chen CJ, Wong KS, et al. Impact of bacterial and viral coinfection on mycoplasmal pneumonia in childhood community-acquired pneumonia[J]. J Microbiol Immunol Infect, 2015, 48(1): 51-56.
Darveaux JI, Lemanske RF Jr. Infection-related asthma[J]. J Allergy Clin Immunol Pract, 2014, 2(6): 658-663.
[25]
Leung TF, Chan PK, Wong GW, et al. Respiratory viruses and atypical bacteria triggering severe asthma exacerbation in children[J]. Hong Kong Med J, 2013, 19 Suppl 4: 11-14.
