[1] Lai MC, Yang SN. Perinatal hypoxic-ischemic encephalopathy[J]. J Biomed Biotechnol, 2011, 2011:609813.
[2] Kurinczuk JJ, White-Koning M, Badawi N. Epidemiology of neonatal encephalopathy and hypoxic-ischaemic encephalopathy[J]. Early Hum Dev, 2010, 86(6):329-338.
[3] Yates HL, McCullough S, Harrison C, et al. Hypoxic ischaemic encephalopathy:accuracy of the reported incidence[J]. Arch Dis Child Fetal Neonatal Ed, 2012, 97(1):F77-F78.
[4] James A, Patel V. Hypoxic ischaemic encephalopathy[J]. Paediatr Child Health, 2014, 24(9):385-389.
[5] Saliba E, Fakhri N, Debillon T. Establishing a hypothermia service for infants with suspected hypoxic-ischemic encephalopathy[J]. Semin Fetal Neonatal Med, 2015, 20(2):80-86.
[6] Wu Q, Chen W, Sinha B, et al. Neuroprotective agents for neonatal hypoxic-ischemic brain injury[J]. Drug Discov Today, 2015, 20(11):1372-1381.
[7] Lv H, Wang Q, Wu S, et al. Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid[J]. Clin Chim Acta, 2015, 450:282-297.
[8] Mckenna MC, Dienel GA, Sonnewald U, et al. Energy metabolism of the brain[M]//Siegel GJ, Albers RW, Price DL. Basic neurochemistry. 8 th ed. New York:Academic Press, 2012:200-231.
[9] Bélanger M, Allaman I, Magistretti PJ. Brain energy metabolism:focus on astrocyte-neuron metabolic cooperation[J]. Cell Metab, 2011, 14(6):724-738.
[10] Drury PP, Bennet L, Gunn AJ. Mechanisms of hypothermic neuroprotection[J]. Semin Fetal Neonatal Med, 2010, 15(5):287-292.
[11] Silveira RC, Procianoy RS. Hypothermia therapy for newborns with hypoxic ischemic encephalopathy[J]. J Pediatr (Rio J), 2015, 91(6 Suppl 1):S78-S83.
[12] Dickinson H, Ellery S, Ireland Z, et al. Creatine supplementation during pregnancy:summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy[J]. BMC Pregnancy Childbirth, 2014, 14:150.
[13] Tagin MA, Woolcott CG, Vincer MJ, et al. Hypothermia for neonatal hypoxic ischemic encephalopathy:an updated systematic review and meta-analysis[J]. Arch Pediatr Adolesc Med, 2012, 166(6):558-566.
[14] Perlman JM, Wyllie J, Kattwinkel J, et al. Part 7:Neonatal resuscitation:2015 international consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations[J]. Circulation, 2015, 132(16 Suppl 1):S204-S241.
[15] Trays G, Banerjee S. Fetal and neonatal hyperthermia[J]. Paediatr Child Health, 2014, 24(9):419-423.
[16] Jacobs SE, Berg M, Hunt R, et al. Cooling for newborns with hypoxic ischaemic encephalopathy[J]. Cochrane Database Syst Rev, 2013, (1):CD003311.
[17] Sarkar S, Barks JD. Systemic complications and hypothermia[J]. Semin Fetal Neonatal Med, 2010, 15(5):270-275.
[18] Rober tson NJ, Tan S, Groenendaal F, et al. Which neuroprotective agents are ready for bench to bedside translation in the newborn infant?[J]. J Pediatr, 2012, 160(4):544-552.e4.
[19] Broad KD, Fierens I, Fleiss B, et al. Inhaled 45-50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia[J]. Neurobiol Dis, 2016, 87:29-38.
[20] Loetscher PD, Rossaint J, Rossaint R, et al. Argon:neuroprotection in in vitro models of cerebral ischemia and traumatic brain injury[J]. Crit Care, 2009, 13(6):R206.
[21] Obel LF, Müller MS, Walls AB, et al. Brain glycogen-new perspectives on its metabolic function and regulation at the subcellular level[J]. Front Neuroenergetics, 2012, 4:3.
[22] Mlody B, Lorenz C, Inak G, et al. Energy metabolism in neuronal/glial induction and in iPSC models of brain disorders[J]. Semin Cell Dev Biol, 2016, 52:102-109.
[23] Shulman RG, Rothman DL, Behar KL, et al. Energetic basis of brain activity:implications for neuroimaging[J]. Trends Neurosci, 2004, 27(8):489-495.
[24] Ellery SJ, Dickinson H, McKenzie M, et al. Dietary interventions designed to protect the perinatal brain from hypoxic-ischemic encephalopathy-Creatine prophylaxis and the need for multi-organ protection[J]. Neurochem Int, 2016, 95:15-23.
[25] Allah Yar R, Akbar A, Iqbal F. Creatine monohydrate supplementation for 10 weeks mediates neuroprotection and improves learning/memory following neonatal hypoxia ischemia encephalopathy in female albino mice[J]. Brain Res, 2015, 1595:92-100.
[26] Iqbal S, Ali M, Iqbal F. Long term creatine monohydrate supplementation, following neonatal hypoxic ischemic insult, improves neuromuscular coordination and spatial learning in male albino mouse[J]. Brain Res, 2015, 1603:76-83.
[27] Iqbal S, Ali M, Akbar A, et al. Effects of dietary creatine supplementation for 8 weeks on neuromuscular coordination and learning in male albino mouse following neonatal hypoxic ischemic insult[J]. Neurol Sci, 2015, 36(5):765-770.
[28] Ellery SJ, LaRosa DA, Kett MM, et al. Maternal creatine homeostasis is altered during gestation in the spiny mouse:is this a metabolic adaptation to pregnancy?[J]. BMC Pregnancy Childbirth, 2015, 15:92.
[29] Ireland Z, Dickinson H, Snow R, et al. Maternal creatine:does it reach the fetus and improve survival after an acute hypoxic episode in the spiny mouse (Acomys cahirinus)?[J]. Am J Obstet Gynecol, 2008, 198(4):431.e1-431.e6.
[30] Ireland Z, Castillo-Melendez M, Dickinson H, et al. A maternal diet supplemented with creatine from mid-pregnancy protects the newborn spiny mouse brain from birth hypoxia[J]. Neuroscience, 2011, 194:372-379.
[31] Dickinson H, Ellery S, Ireland Z, et al. Creatine supplementation during pregnancy:summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy[J]. BMC Pregnancy Childbirth, 2014, 14:150.
[32] Dolder M, Walzel B, Speer O, et al. Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation[J]. J Biol Chem, 2003, 278(20):17760-17766.
[33] Meyer LE, Machado LB, Santiago AP, et al. Mitochondrial creatine kinase activity prevents reactive oxygen species generation:antioxidant role of mitochondrial kinase-dependent ADP re-cycling activity[J]. J Biol Chem, 2006, 281(49):37361-37371.
[34] Guidi C, Potenza L, Sestili P, et al. Differential effect of creatine on oxidatively-injured mitochondrial and nuclear DNA[J]. Biochim Biophys Acta, 2008, 1780(1):16-26.
[35] Turner CE, Byblow WD, Gant N. Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation[J]. J Neurosci, 2015, 35(4):1773-1780.
[36] Sartini S, Lattanzi D, Ambrogini P, et al. Maternal creatine supplementation affects the morpho-functional development of hippocampal neurons in rat offspring[J]. Neuroscience, 2016, 312:120-129.
[37] Andres RH, Ducray AD, Schlattner U, et al. Functions and effects of creatine in the central nervous system[J]. Brain Res Bull, 2008, 76(4):329-343.
[38] Poortmans J, Francaux M. Adverse effects of creatine supplementation:fact or fiction?[J]. Sports Med, 2000, 30(3):155-170.
[39] Dickinson H, Bain E, Wilkinson D, et al. Creatine for women in pregnancy for neuroprotection of the fetus[J]. Cochrane Database Syst Rev, 2014, (12):CD010846.
[40] EL Andaloussi S, Mäger I, Breakefield XO, et al. Extracellular vesicles:biology and emerging therapeutic opportunities[J]. Nat Rev Drug Discov, 2013, 12(5):347-357.
[41] Colombo M, Raposo G, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles[J]. Annu Rev Cell Dev Biol, 2014, 30:255-289.
[42] Zappulli V, Friis KP, Fitzpatrick Z, et al. Extracellular vesicles and intercellular communication within the nervous system[J]. J Clin Invest, 2016, 126(4):1198-1207.
[43] Baulch JE, Acharya MM, Allen BD, et al. Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain[J]. Proc Natl Acad Sci U S A, 2016, 113(17):4836-4841.
[44] Ophelders DR, Wolfs TG, Jellema RK, et al. Mesenchymal stromal cell-derived extracellular vesicles protect the fetal brain after hypoxia-ischemia[J]. Stem Cells Transl Med, 2016, 5(6):754-763.
[45] Arslan F, Lai RC, Smeets MB, et al. Mesenchymal stem cellderived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury[J]. Stem Cell Res, 2013, 10(3):301-312.
[46] Lindoso RS, Collino F, Bruno S, et al. Extracellular vesicles released from mesenchymal stromal cells modulate miRNA in renal tubular cells and inhibit ATP depletion injury[J]. Stem Cells Dev, 2014, 23(15):1809-1819.
[47] Xin H, Li Y, Cui Y, et al. Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats[J]. J Cereb Blood Flow Metab, 2013, 33(11):1711-1715.
[48] Zhang Y, Chopp M, Meng Y, et al. Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury[J]. J Neurosurg, 2015, 122(4):856-867.