Research progress in relationship between fractional exhaled nitric oxide and asthma in children

ZENG Jing; LIAO Wei

doi:10.7499/j.issn.1008-8830.2016.09.022

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Chinese Journal of Contemporary Pediatrics ›› 2016, Vol. 18 ›› Issue (9) : 903-908. DOI: 10.7499/j.issn.1008-8830.2016.09.022

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Research progress in relationship between fractional exhaled nitric oxide and asthma in children

ZENG Jing, LIAO Wei

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Abstract

Bronchial asthma is a heterogeneous disease that is characterized by airway hyperresponsiveness and chronic inflammation. It is often accompanied by reversible airflow obstruction. Current laboratory testing methods for the diagnosis of asthma in children mainly include lung ventilation function test. Due to the non-cooperation of children, it is very challenging to conduct lung ventilation function test for preschoolers. Lung function testing is an instantaneous indicator, which is influenced by the children's understanding ability and mental factors. In addition, it could not assess the severity of airway inflammation. Fractional exhaled nitric oxide (FeNO) is a noninvasive, simple, and objective indicator of airway inflammation and has gradually gained increased use in children in recent years. This review article introduces the source of FeNO, the reference value of FeNO in laboratory testing, and the progress in the application of FeNO in the diagnosis, prediction, and treatment of asthma in children of various ages.

Key words

Asthma / Lung function / Fractional exhaled nitric oxide / Child

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ZENG Jing, LIAO Wei. Research progress in relationship between fractional exhaled nitric oxide and asthma in children[J]. Chinese Journal of Contemporary Pediatrics. 2016, 18(9): 903-908 https://doi.org/10.7499/j.issn.1008-8830.2016.09.022

References

[1] Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline:interpretation of exhaled nitric oxide levels (FENO) for clinical applications[J].Am J Respir Crit Care Med, 2011, 184(5):602-615.
[2] Hanson JR, De Lurgio SA, Williams DD, et al. Office-based exhaled nitric oxide measurement in children 4 years of age and older[J]. Ann Allergy Asthma Immunol, 2013, 111(5):358-363.
[3] Kalliola S, Malmberg P, Rito T, et al. Can we use portable nitric oxide analyzer in young children?[J]. Pediatr Pulmonol, 2011, 46(7):627-631.
[4] 赵丽敏, 马利军. 呼出气一氧化氮检测及临床意义[J]. 中华实用诊断与治疗杂志, 2011, 25(5):422-423.
[5] Vital AL, Gonçalo M, Cruz MT, et al. Dexamethasone prevents granulocyte-macrophage colony-stimulating factor-induced nuclear factor-kappaB activation, inducible nitric oxide synthase expression and nitric oxide production in a skin dendritic cell line[J]. Mediators Inflamm, 2003, 12(2):71-78.
[6] Mahr TA, Malka J, Spahn JD. Inflammometry in pediatric asthma:a review of fractional exhaled nitric oxide in clinical practice[J]. Allergy Asthma Proc, 2013, 34(3):210-219.
[7] Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics[J]. Eur Respir J, 1993, 6(9):1368-1370.
[8] Sivan Y, Gadish T, Fireman E, et al. The use of exhaled nitric oxide in the diagnosis of asthma in school children[J]. J Pediatr, 2009, 155(2):211-216.
[9] 安淑华, 田文秋, 李金英. 呼出气一氧化氮检测在幼儿支气管哮喘中的应用分析[J]. 中国当代儿科杂志, 2015, 17(2):134-137.
[10] 曹兴丽, 武怡. 呼出气一氧化氮在儿童咳嗽变异性哮喘诊断中的价值[J]. 徐州医学院学报, 2015, 35(5):328-330.
[11] 朱海艳, 于兴梅, 郝创利, 等. 呼出气一氧化氮测定对儿童咳嗽变异性哮喘的诊断价值[J]. 中华结核和呼吸杂志, 2015, 38(5):352-355.
[12] 王天玥, 尚云晓, 张晗. 呼出气一氧化氮浓度测定在儿童支气管哮喘和咳嗽变异性哮喘中的诊断价值[J]. 中国当代儿科杂志, 2015, 17(8):800-805.
[13] 陈澄, 张秀琴, 沈续瑞, 等. 呼出气一氧化氮鉴别典型哮喘及咳嗽变异性哮喘价值初探[J]. 国际呼吸杂志, 2015, 35(20):1541-1544.
[14] Cordeiro D, Rudolphus A, Snoey E, et al. Utility of nitric oxide for the diagnosis of asthma in an allergy clinic population[J]. Allergy Asthma Proc, 2011, 32(2):119-126.
[15] Kotaniemi-Syrjänen A, Malmberg LP, Malmström K, et al. Factors associated with elevated exhaled nitric oxide fraction in infants with recurrent respiratory symptoms[J]. Eur Respir J, 2013, 41(1):189-194.
[16] Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline:interpretation of exhaled nitric oxide levels (FENO) for clinical applications[J]. Am J Respir Crit Care Med, 2011, 184(5):602-615.
[17] 刘媛媛, 陆燕红, 郝创利. 以225名健康儿童建立呼出气一氧化氮正常值[J]. 中国循证儿科杂志, 2012, 7(2):132-135.
[18] Linn WS, Rappaport EB, Eckel SP, et al. Multiple-flow exhaled nitric oxide, allergy, and asthma in a population of older children[J]. Pediatr Pulmonol, 2013, 48(9):885-896.
[19] Jartti T, Wendelin-Saarenhovi M, Heinonen I, et al. Childhood asthma management guided by repeated FeNO measurements:a meta-analysis[J]. Paediatr Respir Rev, 2012, 13(3):178-183.
[20] Cibella F, Cuttitta G, La Grutta S, et al. A cross-sectional study assessing the relationship between BMI, asthma, atopy, and eNO among schoolchildren[J]. Ann Allergy Asthma Immunol, 2011, 107(4):330-336.
[21] van der Heijden HH, Brouwer ML, Hoekstra F, et al. Reference values of exhaled nitric oxide in healthy children 1-5 years using off-line tidal breathing[J]. Pediatr Pulmonol, 2014, 49(3):291-295.
[22] The Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma(GINA)2015[DB/OL].[2016-01-03]. http://www.ginasthma.org/documents/4.
[23] Wenzel SE. Asthma:defining of the persistent adult phenotypes[J]. Lancet, 2006, 368(9537):804-813.
[24] Simpson JL, Scott R, Boyle MJ, et al. Inflammatory subtypes in asthma:assessment and identification using induced sputum[J]. Respirology, 2006, 11(1):54-61.
[25] 刘娜, 赵德育, 吴美思, 等. 呼出气一氧化氮测定对儿童支气管哮喘的诊断价值[J]. 南京医科大学学报(自然科学版):自然科学版, 2011, 31(4):553-556.
[26] 中华医学会儿科分会呼吸学组, 《中华儿科杂志》编辑委员会.儿童支气管哮喘诊断与防治指南(2016年版)[J]. 中华儿科杂志, 2016, 54(3):167-181.
[27] 江爱萍. 呼出气一氧化氮测定在儿童呼吸道疾病诊断中的应用[J]. 社区医学杂志, 2015, 13(8):23-24.
[28] 丁静, 赵德育, 吴美思. 支气管哮喘患儿呼出气一氧化氮的变化及其与肺功能的相关性[J]. 中华实用儿科临床杂志, 2015, 30(22):1729-1731.
[29] Sachs-Olsen C, Lødrup Carlsen KC, Mowinckel P, et al. Diagnostic value of exhaled nitric oxide in childhood asthma and allergy[J]. Pediatr Allergy Immunol, 2010, 21(1 Pt 2):e213-e221.
[30] Covar RA, Szefler SJ, Martin RJ, et al. Relations between exhaled nitric oxide and measures of disease activity among children with mild-to-moderate asthma[J]. J Pediatr, 2003, 142(5):469-475.
[31] Sardón-Prado O, Korta-Murua J, Valverde-Molina J, et al. Association among lung function, exhaled nitric oxide, and the CAN questionnaire to assess asthma control in children[J]. Pediatr Pulmonol, 2010, 45(5):434-439.
[32] 高虹, 刘艳琳, 陈燊, 等. 哮喘儿童呼出气一氧化氮与肺通气功能、激发试验、哮喘控制测试评分相关性研究[J]. 中国中西医结合儿科学, 2014, 6(2):119-121.
[33] 刘莎, 龚财惠, 符州. 呼出气一氧化氮在儿童哮喘缓解期的应用价值[J]. 重庆医学, 2015, 44(8):1085-1090.
[34] Balinotti JE, Colom A, Kofman C, et al. Association between the Asthma Predictive Index and levels of exhaled nitric oxide in infants and toddlers with recurrent wheezing[J]. Arch Argent Pediatr, 2013, 111(3):191-195.
[35] Singer F, Luchsinger I, Inci D, et al. Exhaled nitric oxide in symptomatic children at preschool age predicts later asthma[J]. Allergy, 2013, 68(4):531-538.
[36] Gabriele C, Jaddoe VW, van Mastrigt E, et al. Exhaled nitric oxide and the risk of wheezing in infancy:the Generation R Study[J]. Eur Respir J, 2012, 39(3):567-572.
[37] Schmalisch G, Wilitzki S, Fischer HS, et al. Effect of intubation and mechanical ventilation on exhaled nitric oxide in preterm infants with and without bronchopulmonary dysplasia measured at a median postmenstrual age of 49 weeks[J]. BMC Res Notes, 2014, 7:389.
[38] Lee JW, Shim JY, Kwon JW, et al. Exhaled nitric oxide as a better diagnostic indicator for evaluating wheeze and airway hyperresponsiveness in preschool children[J]. J Asthma, 2015, 52(10):1054-1059.
[39] 侯萍, 单丽沈, 蔡栩栩, 等. 哮喘儿童呼出气一氧化氮与肺通气功能及哮喘控制测试相关性研究[J]. 中国实用儿科杂志, 2014, 29(9):708-712.
[40] 向莉, 付亚南, 李珍, 等. 不同控制水平的哮喘患儿呼出气一氧化氮浓度水平及其临床意义[J]. 中国当代儿科杂志, 2013, 15(1):29-32.
[41] Verini M, Consilvio NP, Di Pillo S, et al. FeNO as a Marker of Airways Inflammation:The Possible Implications in Childhood Asthma Management[J]. J Allergy (Cairo), 2010, 2010. pii:691425.
[42] 刘晓颖, 王静, 王群, 等. 哮喘患儿对长程控制治疗反应性的差异及其相关因素分析[J]. 中国当代儿科杂志, 2015, 17(7):692-697.
[43] 曾彩霞, 孙中厚, 安百梅, 等. 呼出气一氧化氮浓度在婴幼儿喘息性疾病中的意义[J]. 现代医药卫生, 2015, 31(8):1127-1130.
[44] Elmasri M, Romero KM, Gilman RH, et al. Longitudinal assessment of high versus low levels of fractional exhaled nitric oxide among children with asthma and atopy[J]. Lung, 2014, 192(2):305-312.
[45] Beck-Ripp J, Griese M, Arenz S, et al. Changes of exhaled nitric oxide during steroid treatment of childhood asthma[J]. Eur Respir J, 2002, 19(6):1015-1019.
[46] Lanz MJ, Bautista AP, Peyrou NM, et al. Exhaled nitric oxide in young, symptomatic patients with atopic asthma receiving nebulized budesonide therapy[J]. Ann Allergy Asthma Immunol, 2010, 105(5):400-401.
[47] 张东伟, 张光莉, 李俊奇, 等. 特异质与慢性持续期哮喘儿童呼出气一氧化氮相关性研究[J]. 临床儿科杂志, 2015, 33(2):109-112.
[48] Petsky HL, Cates CJ, Lasserson TJ, et al. A systematic review and meta-analysis:tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils)[J]. Thorax, 2012, 67(3):199-208.
[49] Pijnenburg MW, Szefler S. Personalized medicine in children with asthma[J]. Paediatr Respir Rev, 2015, 16(2):101-107.
[50] 张玉梅, 潘太娟. 孟鲁司特对咳嗽变异性哮喘FEF25%~75%/FVC及FeNO的影响[J]. 中国实用医药, 2015, 10(20):1-2.
[51] Montuschi P, Mondino C, Koch P, et al. Effects of montelukast treatment and withdrawal on fractional exhaled nitric oxide and lung function in children with asthma[J]. Chest, 2007, 132(6):1876-1881.
[52] Peirsman EJ, Carvelli TJ, Hage PY, et al. Exhaled nitric oxide in childhood allergic asthma management:a randomised controlled trial[J]. Pediatr Pulmonol, 2014, 49(7):624-631.
[53] Silvestri M, Sabatini F, Sale R, et al. Correlations between exhaled nitric oxide levels, blood eosinophilia, and airway obstruction reversibility in childhood asthma are detectable only in atopic individuals[J]. Pediatr Pulmonol, 2003, 35(5):358-363.
[54] Colon-Semidey AJ, Marshik P, Crowley M, et al. Correlation between reversibility of airway obstruction and exhaled nitric oxide levels in children with stable bronchial asthma[J]. Pediatr Pulmonol, 2000, 30(5):385-392.
[55] Zhao H, Li R, Lv Y, et al. Albuterol inhalation increases FeNO level in steroid-naive asthmatics but not COPD patients with reversibility[J]. Clin Respir J, 2015.