Immunological mechanism of wheezing attack in children with cytomegalovirus infection

ZHU Xiao-Hua; CHEN Qiang; LI Qiu-Gen; LI Lan; KE Jiang-Wei; LIU Zhi-Qiang; RAN Fei

doi:10.7499/j.issn.1008-8830.2016.09.009

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Chinese Journal of Contemporary Pediatrics ›› 2016, Vol. 18 ›› Issue (9) : 831-834. DOI: 10.7499/j.issn.1008-8830.2016.09.009

CLINICAL RESEARCH

Immunological mechanism of wheezing attack in children with cytomegalovirus infection

ZHU Xiao-Hua^1,2, CHEN Qiang², LI Qiu-Gen³, LI Lan², KE Jiang-Wei⁴, LIU Zhi-Qiang⁴, RAN Fei⁴

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Abstract

Objective To study the possible immunological mechanism of wheezing attack in children with cytomegalovirus (CMV) infection. Methods A total of 25 under-5-year-old children with wheezing following CMV infection were enrolled. The expression of serum regulatory T cells (Treg)/T helper 17 (Th17) cytokines interleukin (IL)-10, IL-6, and IL-17, and peripheral blood lymphocyte subsets were determined. Twenty age-matched healthy children were selected as the control group. Results The wheezing group had a significantly reduced serum IL-10 level, significantly increased IL-6 and IL-17 levels, significantly reduced levels of natural killer cells, and significantly increased levels of CD8⁺ T cells and CD19⁺ B cells, as compared with the control group. Conclusions Wheezing children with CMV infection have Treg/Th17 imbalance and cellular immune dysfunction, which may be an important immunological mechanism of the development of wheezing in children after CMV infection.

Key words

Cytomegalovirus infection / Wheezing / Immunological mechanism / Child

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ZHU Xiao-Hua, CHEN Qiang, LI Qiu-Gen, LI Lan, KE Jiang-Wei, LIU Zhi-Qiang, RAN Fei. Immunological mechanism of wheezing attack in children with cytomegalovirus infection[J]. Chinese Journal of Contemporary Pediatrics. 2016, 18(9): 831-834 https://doi.org/10.7499/j.issn.1008-8830.2016.09.009

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