Objective To investigate the non-high-density lipoprotein cholesterol (non-HDL-C) level and the prevalence rate of a high non-HDL-C level in children aged 9-11 years in the Mianyang Science City area in Sichuan Province, China. Methods From September to October, 2015, a field investigation was performed for the students from three primary schools in the Mianyang Science City area by cluster sampling. Fasting venous blood was collected for blood lipid tests. The cut-off value of serum non-HDL-C level and prevalence rate of a high non-HDL-C level in children aged 9-11 years in this area were calculated, as well as the prevalence rate of a high non-HDL-C level in obese children. Results In the children aged 9-11 years in this area, the cut-off value of non-HDL-C level was 3.67 mmol/L, and the prevalence rate of a high non-HDL-C level was 3.7% (22/589). Compared with the non-obese children, the obese children had a significantly higher serum non-HDL-C level (P < 0.01) and a significantly higher prevalence rate of a high non-HDL-C level (10.0% vs 2.9%; P < 0.01). Conclusions The cut-off value of serum non-HDL-C level in children aged 9-11 years in the Mianyang Science City area is established. Obesity is associated with an increased prevalence rate of a high non-HDL-C level in children aged 9-11 years.
Key words
Non-high-density lipoprotein cholesterol /
Prevalence /
Obesity /
Cut-off value /
Child
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References
[1] Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report[J]. Pediatrics, 2011, 128 (Suppl 5): S213-S256.
[2] 许积德. 青春期的发育[M]//刘湘云, 陈荣华. 儿童保健学. 第3 版. 南京:江苏科学技术出版社, 2005: 20-24.
[3] 中华医学会儿科学分会内分泌遗传代谢学组, 中华医学会儿 科学分会心血管学组, 中华医学会儿科学分会儿童保健学 组. 中国儿童青少年代谢综合征定义和防治建议[J].中华 儿科杂志, 2012, 50(6): 420-422.
[4] 李辉, 季成叶, 宗心南, 等. 中国0~18 岁儿童、青少年体块 指数的生长曲线[J]. 中华儿科杂志, 2009, 47(7): 493-498.
[5] Srinivasan SR, Frontini MG, Xu J, et al. Utility of childhood non-high-density lipoprotein cholesterol levels in predicting adult dyslipidemia and other cardiovascular risks: the Bogalusa Heart Study[J]. Pediatrics, 2006, 118(1): 201-206.
[6] Boekholdt SM, Arsenault BJ, Mora S, et al. Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis[J]. JAMA, 2012, 307(12): 1302-1309.
[7] 陈联辉,朱伟芬,梁黎, 等. 非高密度脂蛋白胆固醇对肥胖 儿童非脂性心血管疾病危险因素的预测作用[J]. 中国当代儿 科杂志, 2013, 15(5): 356-360.
[8] 焦朝艳, 刘戈力, 鲍鹏丽, 等. 肥胖儿童non-HDL-C、 remnant cholesterol 与亚临床动脉粥样硬化的关系[J]. 天津医 科大学学报, 2014, 20(1): 25-28.
[9] Graham I, Atar D, Borch-Johnsen K, et al. European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts)[J]. Eur Heart J, 2007, 28(19): 2375-2414.
[10] Li C, Ford ES, McBride PE, et al. Non-high-density lipoprotein cholesterol concentration is associated with the metabolic syndrome among US youth aged 12-19 years[J]. J Pediatr, 2011, 158(2): 201-207.
[11] 朱建芳, 梁黎, 傅君芬, 等. 中国6 市7~16 岁中小学生血 脂水平现状调查[J]. 中华流行病学杂志, 2012, 33(10): 1005-1009.
[12] 季成叶, 陈天娇. 中国儿童青少年1995-2010 年皮褶厚度和 体脂率变化情况[J]. 中国学校卫生, 2013, 34(7): 772-778.