Abstract Objective To study the changes in serum levels of cortisol and adrenocorticotropic hormone (ACTH) in children with septic shock (SS) and to explore their relationship with the disease severity and prognosis. Methods Twenty-five children with decompensated SS and 24 children with early SS were enrolled. Serum cortisol and ACTH levels were determined on admission and days 3 and 8 after admission. Twenty-five healthy children were used as the control group. The children with decompensated SS were further divided into death group (n=5) and survival group (n=20) based on their clinical outcome. Results On admission, the decompensated SS and early SS groups had significantly higher serum cortisol and ACTH levels than the control group (P P P P P Conclusions Children with SS have increased serum cortisol and ACTH levels, which are associated with the disease severity. A persistent high serum cortisol level indicates a poor prognosis. Dynamic monitoring of serum cortisol and ACTH levels in children with SS is of great significance in evaluating the disease severity and prognosis.
LIN Hai,WANG Zi-Jing,WANG Shi-Biao et al. Changes in serum cortisol and adrenocorticotropic hormone in children with sepsis shock and their clinical significance[J]. CJCP, 2016, 18(10): 1009-1012.
LIN Hai,WANG Zi-Jing,WANG Shi-Biao et al. Changes in serum cortisol and adrenocorticotropic hormone in children with sepsis shock and their clinical significance[J]. CJCP, 2016, 18(10): 1009-1012.
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