Abstract Breastfeeding is well-known for its benefits of preventing communicable and non-communicable diseases. Human breastmilk consists not only of nutrients, but also of bioactive substances. What's more, the epigenetic effects of human breast milk may also play an important role. Alterations in the epigenetic regulation of genes may lead to profound changes in phenotype. Clarifying the role of human breast milk on genetic expression can potentially benefit the infant's health and his later life. This review article makes a brief summary of the epigenetic mechanism of breast milk, and its epigenetic effects on neonatal necrotizing enterocolitis, infectious diseases, metabolism syndrome, cognitive function and anaphylactic diseases.
World Health Organization. Long-Term effects of breastfeeding: a systematic review[EB/OL]. (2014-04-19).
[4]
Mead MN. Nutrigenomics: the genome-food interface[J]. Environ Health Perspect, 2007, 115(12): A582-589.
[5]
Verduci E, Banderali G, Barberi S, et al. Epigenetic effects of human breast milk[J]. Nutrients, 2014, 6(4): 1711-1724.
[6]
Stover PJ, Caudill MA. Genetic and epigenetic contributions to human nutrition and health: managing genome-diet interactions[J]. J Am Diet Assoc, 2008, 108(9): 1480-1487.
[7]
Waterland RA, Michels KB. Epigenetic epidemiology of the developmental origins hypothesis[J]. Annu Rev Nutr, 2007, 27: 363-388.
[8]
Cutfield WS, Hofman PL, Mitchell M, et al. Could epigenetics play a role in the developmental origins of health and disease[J] Pediatr Res, 2007, 61(5 Pt 2): 68R-75R.
Langley-Evans SC. Nutrition in early life and the programming of adult disease: a review[J]. J Hum Nutr Diet, 2015, 28(Suppl 1): 1-14.
[11]
Trujillo E, Davis C, Milner J. Nutrigenomics,proteomics, metabolomics, and the practice of dietetics[J]. J Am Diet Assoc, 2006, 106(3): 403-413.
[12]
Minekawa R, Takeda T, Sakata M, et al. Human breast milk suppresses the transcriptional regulation of IL-1beta-induced NF-κB signaling in human intestinal cells[J]. Am J Physiol Cell Physiol, 2004, 287(5): C1404-1411.
[13]
Choi SW, Friso S. Epigenetics: A new bridge between nutrition and health[J]. Adv Nutr, 2010, 1(1): 8-16.
[14]
Lillycrop KA, Slater-Jefferies JL, Hanson MA,et al. Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a proteinrestricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications[J]. Br J Nutr, 2007, 97(6): 1064-1073.
[15]
Shi L, Oberdoerffer P. Chromatin dynamics in DNA doublestrand break repair[J]. Biochim Biophys Acta, 2012, 1819(7): 811-819.
[16]
Rosen ED, Sarraf P, Troy AE, et al. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro[J]. Mol Cell, 1999, 4(4): 611-617.
[17]
Wang F, Liu H, Blanton WP, et al. Brd2 disruption in mice causes severe obesity without type 2 diabetes[J]. Biochem J, 2009, 425(1): 71-83.
[18]
Verier C, Meirhaeghe A, Bokor S, et al. Breast-feeding modulates the influence of the peroxisome proliferator-activated receptor-gamma (PPARG2) Pro12Ala polymorphism on adiposity in adolescents: The Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study[J]. Diabetes Care, 2010, 33(1): 190-196.
[19]
Cirera S, Birck M, Busk PK, et al. Expression profiles of miRNA-122 and its target CAT1 in minipigs (Sus scrofa) fed a high-cholesterol diet[J]. Comp Med, 2010, 60(2): 136-141.
[20]
Section on breastfielding. Breastfeeding and the use of human milk[J]. Pediatrics, 2012, 129(3): e827-e841.
[21]
Ballard O, Morrow AL. Human milk composition: nutrients and bioactive factors[J]. Pediatr Clin North Am, 2013, 60(1): 49-74.
[22]
Mulligan P, White NR, Monteleone G, et al. Breast milk lactoferrin regulates gene expression by binding bacterial DNA CpG motifs but not genomic DNA promoters in model intestinal cells[J]. Pediatr Res, 2006, 59(5): 656-661.
[23]
Britigan BE, Lewis TS, Waldschmidt M, et al. Lactoferrin binds CpG-containing oligonucleotides and inhibits their immunostimulatory effects on human B cells[J]. J Immunol, 2001, 167(5): 2921-2928.
[24]
Li R, Dee D, Li CM, Hoffman HJ et al. Breastfeeding and risk of infections at 6 years[J]. Pediatrics, 2014, 134(Suppl 1): S13-20.
[25]
Hanson LA. Breastfeeding provides passive and likely longlasting active immunity[J]. Ann Allergy Asthma Immunol, 1998, 81(6): 523-533.
[26]
Patel JA, Nair S, Revai K, et al. Association of proinflammatory cytokines gene polymorphisms with susceptibility to otitis media[J]. Pediatrics, 2006, 118(6): 2273-2279.
[27]
Miljanović O, Cikota-Aleksić B, Likić D, et al. Association of cytokine gene polymorphisms and risk factors with otitis media proneness in children[J]. Eur J Pediatr, 2016, 175(6): 809-815.
[28]
Barker DJ. Developmental origins of chronic disease[J]. Public Health 2012, 126(3): 185-189.
[29]
Koletzko B, Brands B, Poston L, et al. Early Nutrition Project. Early nutrition programming of long-term health[J]. Proc Nutr Soc, 2012, 71(3): 371-378.
[30]
Abarin T, Yan Wu Y, Warrington N, et al. The impact of breastfeeding on FTO-related BMI growth trajectories: an application to the Raine pregnancy cohort study[J]. Int J Epidemiol, 2012, 41(6): 1650-1660.
[31]
Agostoni C, Baselli L, Mazzoni MB. Early nutrition patterns and diseases of adulthood: A plausible link[J]. Eur J Intern Med, 2013, 24(1): 5-10.
[32]
Owen CG, Whincup PH, Kaye SJ, et al. Does initial breastfeeding lead to lower blood cholesterol in adult life? A quantitative review of the evidence[J]. Am J Clin Nutr, 2008, 88(2): 305-314.
[33]
Boschetti E, Di Nunzio M, Danesi F, et al. Influence of genotype on the modulation of gene and protein expression by n-3 LCPUFA in rats[J]. Genes Nutr, 2013, 8(6): 589-600.
[34]
Mortensen EL, Michaelsen KF, Sanders SA, et al. The association between duration of breastfeeding and adult intelligence[J]. JAMA, 2002, 287(18): 2365-2371.
[35]
Der G, Batty GD, Deary IJ. Effect of breast feeding on intelligence in children: prospective study, sibling pairs analysis, and meta-analysis[J]. BMJ, 2006, 333(7575): 945.
[36]
Belfort MB, Rifas-Shiman SL, Kleinman KP, et al. Infant feeding and childhood cognition at ages 3 and 7 years: Effects of breastfeeding duration and exclusivity[J]. JAMA Pediatr, 2013, 167(9): 836-844.
[37]
Rozé JC, Darmaun D, Boquien CY, et al. The apparent breastfeeding paradox in very preterm infants: relationship between breast feeding, early weight gain and neurodevelopment based on results from two cohorts, EPIPAGE and LIFT[J]. BMJ Open, 2012, 2(2): e000834.
[38]
Heijmans BT, Tobi EW, Stein AD, et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans[J]. Proc Natl Acad Sci USA, 2008, 105(44): 17046-17049.
[39]
Chen DY, Stern SA, Garcia-Osta A, et al. A critical role for IGFII in memory consolidation and enhancement[J]. Nature, 2011, 469(7331): 491-497.
[40]
Caspi A, Williams B, Kim-Cohen J, et al. Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism[J]. Proc Natl Acad Sci USA, 2007, 104(47): 18860-18865.
[41]
Soto-Ramírez N, Karmaus W, Zhang H, et al. Modes of infant feeding and the occurrence of coughing/wheezing in the first year of life[J]. J Hum Lact, 2013, 29(1): 71-80.
[42]
Thygarajan A, Burks AW. American Academy of Pediatrics recommendations on the effects of early nutritional interventions on the development of atopic disease[J]. Curr Opin Pediatr, 2008, 20(6): 698-702.
[43]
Dogaru CM, Nyffenegger D, Pescatore AM, et al. Breastfeeding and childhood asthma: systematic review and meta-analysis[J]. Am J Epidemiol, 2014, 179(10): 1153-1167.
[44]
Hong X, Wang G, Liu X, et al. Gene polymorphisms, breastfeeding, and development of food sensitization in early childhood[J]. J Allergy Clin Immunol, 2011, 128(2): 374-381.
[45]
Lockett GA, Patil VK, Soto-Ramírez N, et al. Epigenomics and allergic disease[J]. Epigenomics, 2013, 5(6): 685-699.
[46]
Rossnerova A, Tulupova E, Tabashidze N, et al. Factors affecting the 27K DNA methylation pattern in asthmatic and healthy children from locations with various environments[J]. Mutat Res, 2013, 741-742: 18-26.
