Association between IL-6 C-572G and susceptibility to spontaneous preterm birth

YANG Xiao; PENG Wei; ZHU Li-Na; ZHANG Xiao-Ai; WANG Yan

doi:10.7499/j.issn.1008-8830.2017.07.015

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Chinese Journal of Contemporary Pediatrics ›› 2017, Vol. 19 ›› Issue (7) : 806-811. DOI: 10.7499/j.issn.1008-8830.2017.07.015

CLINICAL RESEARCH

Association between IL-6 C-572G and susceptibility to spontaneous preterm birth

YANG Xiao^1,2,3, PENG Wei^1,2,3, ZHU Li-Na^1,2,3, ZHANG Xiao-Ai⁴, WANG Yan^1,2,3

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Abstract

Objective To investigate the association between the genetic polymorphism of IL-6 C-572G and susceptibility to spontaneous preterm birth (SPTB). Methods The subjects were from Beijing and the surrounding areas of Beijing. This case-control study enrolled 569 SPTB infants, including 56 extremely preterm ( < 28 weeks of gestation), 166 very preterm (28-31⁺⁶ weeks of gestation) and 347 moderate to late preterm infants (32 to 36⁺⁶ weeks of gestation). A total of 673 term infants were enrolled as the control group. The latest Sequenom MassARRAY^®SNP detection technique was used for the typing of single nucleotide polymorphism of IL-6 C-572G. Results Compared with the CC genotypes, the IL-6 C-572G G-positive genotype (CG+GG genotype) was signifcantly associated with an increased susceptibility to moderate to late SPTB (OR=1.35, 95%CI:1.01-1.80, P=0.04). Conclusions Among the Chinese population, IL-6 C-572G polymorphism is associated with susceptibility to moderate to late SPTB.

Key words

Interleukin 6 / Spontaneous preterm birth / Single nucleotide polymorphism / Susceptibility / Preterm infant

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YANG Xiao, PENG Wei, ZHU Li-Na, ZHANG Xiao-Ai, WANG Yan. Association between IL-6 C-572G and susceptibility to spontaneous preterm birth[J]. Chinese Journal of Contemporary Pediatrics. 2017, 19(7): 806-811 https://doi.org/10.7499/j.issn.1008-8830.2017.07.015

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