PDF(1404 KB)
Quantitative evaluation of white matter development in fetus with growth restriction by diffusion tensor imaging
WANG Hua-Wei, WU Bing, LIU Jing, LIU Fang, WU Xin-Huai, GE Ming-Mei
Chinese Journal of Contemporary Pediatrics ›› 2017, Vol. 19 ›› Issue (8) : 887-892.
PDF(1404 KB)
PDF(1404 KB)
Quantitative evaluation of white matter development in fetus with growth restriction by diffusion tensor imaging
Objective To investigate whether fetal growth restriction (FGR) has an adverse effect on white matter development.Methods A total of 28 full-term small for gestational age (SGA) infants were enrolled as study subjects and 15 full-term appropriate for gestational age infants were enrolled as control group. Conventional head magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were performed for all infants. The white matter was divided into 122 regions. The two groups were compared in terms of fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity of different brain regions.Results Compared with the control group, the SGA group had a significantly lower fractional anisotropy in 16 brain regions (P < 0.01), a significantly higher mean diffusivity in 7 brain regions (P < 0.05), a significantly higher axial diffusivity in 8 brain regions (P < 0.05), and a significantly higher radial diffusivity in 16 brain regions (P < 0.05).Conclusions FGR may cause abnormalities in the maturity and integrity of white matter fiber tracts.
Fetal growth restriction / White matter injury / Diffusion tensor imaging / Small for gestational age infant
[1] 王晓凤, 曾军安, 刘敬, 等. 胎儿宫内生长受限发生率调查及其对胎儿-新生儿健康危害的研究[J].中国儿童保健杂志, 2013, 21 (10): 1020-1023.
[2] Longo S, Bolani L, Decembrino L, et al. Short-term and long-term sequelae in intrauterine growth retardation (IUGR) [J]. J Matern Fetal Neonatal Med, 2013, 26 (3): 222-225.
[3] Liu J, Liu L, Chen H. Antenatal taurine supplementation for improving brain ultrastructure in fetal rats with intrauterine growth restriction[J]. Neurosci, 2011, 181: 265-270.
[4] Samuelsen GB, Pakkenberg B, Bogdanovi? N, et al. Severe cell reduction in the future brain cortex in human growth-restricted fetuses and infants[J]. Am J Obstet Gynecol, 2007, 197 (1): 56.e1-7.
[5] van Pul C, van Kooij BJ, de Vries LS, et al. Quantitative fiber tracking in the corpus callosum and internal capsule reveals microstructural abnormalities in preterm infants at term-equivalent age[J]. AJNR Am J Neuroradiol, 2012, 33 (4): 678-684.
[6] Liu Y, Aeby A, Balériaux D, et al. White matter abnormalities are related to microstructural changes in preterm neonates at term-equivalent age: a diffusion tensor imaging and probabilistic tractography study[J]. AJNR Am J Neuroradiol, 2012, 33 (5): 839-845.
[7] Estrin GL, Kyriakopoulou V, Makropoulos A, et al. Altered white matter and cortical structure in neonates with antenatally diagnosed isolated ventriculomegaly[J]. Neuroimage Clin, 2016, 11: 139-148.
[8] Oishi K, Mori S, Donohue PK, et al. Multi-contrast human neonatal brain atlas: application to normal neonate development analysis[J]. Neuroimage, 2011, 56 (1): 8-20.
[9] Berman JI, Mukherjee P, Partridge SC, et al. Quantitative diffusion tensor MRI fiber tractography of sensorimotor white matter development in premature infants[J]. Neuroimage, 2005, 27 (4): 862-871.
[10] Ulu? AM, van Zijl PC. Orientation-independent diffusion imaging without tensor diagonalization: Anisotropy definitions based on physical attributes of the diffusion ellipsoid[J]. J Magn Reson Imaging, 1999, 9 (6): 804-813.
[11] Chen Y, An H, Zhu H, et al. Longitudinal regression analysis of spatial–temporal growth pattern of geometrical diffusion measures in early postnatal brain development with diffusiontensor imaging[J]. Neuroimage, 2011, 58 (4): 993-1005.
[12] Brissaud O, Amirault M, Villega F, et al. Efficiency of fractional anisotropy and apparent diffusion coefficient on diffusion tensor imaging in prognosis of neonates with hypoxic-ischemic encephalopathy: a methodologic prospective pilot study[J]. AJNR Am J Neuroradio, 2010, 31 (2): 282-287.
[13] Ancora G, Testa C, Grandi S, et al. Prognostic value of brain proton MR spectroscopy and diffusion tensor imaging in newborns with hypoxic-ischemic encephalopathy treated by brain cooling[J]. Neuroradiology, 2013, 55 (8): 1017-1025.
[14] Bonifacioa SL, Saporta A, Glass HC, et al. Therapeutic hypothermia for neonatal encephalopathy results in improved microstructure and metabolism in the deep gray nuclei[J]. AJNR Am J Neuroradiol, 2012, 33 (11): 2050-2055.
[15] Snook L, Paulson LA, Roy D, et al. Diffusion tensor imaging of neurodevelopment in children and young adults[J]. Neuroimage, 2005, 26 (4): 1164-1173.
[16] Shi Y, Short SJ, Knickmeyer RC, et al. Styner diffusion tensor imaging based characterization of brain neurodevelopment in primates[J]. Cereb Cortex, 2013, 23 (1): 36-48.
[17] Skiöld B, Horsch S, Hallberg B, et al. White matter changes in extremely preterminfants, a population-based diffusion tensor imaging study[J]. Acta Paediatr, 2010, 99 (6): 842-849.
[18] Uda S, Matsui M, Tanaka C, et al. Normal development of human brain white matter from infancy to early adulthood: a diffusion tensor imaging study[J]. Dev Neurosci, 2015, 37 (2): 182-194.
[19] Montgomery LR, Herbert WJ, Buford JR. Recruitment of ipsilateral and contralateral upper limb muscles following stimulation of the cortical motor areas in the monkey[J]. Exp Brain Res, 2013, 230 (2): 153-164.
[20] Provenzale JM, Liang L, DeLong D, et al. Diffusion tensor imaging assessment of brain white matter maturation during the first postnatal year[J]. AJR Am J Roentgenol, 2007, 189 (2): 476-486.
[21] Deoni SC, Mercure E, Blasi A, et al. Mapping infant brain myelination with magnetic resonance imaging[J]. J Neurosci, 2011, 31 (2): 784-791.
[22] James A, Christian Z, Riddle A, et al. Central axons preparing to myelinate are highly sensitivity to ischemic injury[J]. Ann Neurol, 2012, 72 (6): 936-951.
[23] Hasegawa T, Yamada K, Morimoto M, et al. Development of corpus callosum in preterm infants is affected by the prematurity: in vivo assessment of diffusion tensor imaging at term-equivalent age[J]. Pediatr Res, 2011, 69 (3): 249-254.
[24] Mullen KM, Vohr BR, Katz KH, et al. Preterm birth results in alterations in neural connectivity at age 16 years[J]. Neuroimage, 2011, 54 (4): 2563-2570.
[25] Nossin-Manor R, Card D, Morris D, et al. Quantitative MRI in the very preterm brain: assessing tissue organization and myelination using magnetization transfer, diffusion tensor and T1 imaging[J]. Neuroimage, 2013, 64: 505-516.
