Abstract Objective To study the reference ranges of six sex hormones, i.e., luteinizing hormone, follicle-stimulating hormone, progesterone, prolactin, estradiol, and testosterone, for healthy children aged 0-18 years in Shenzhen, China. Methods Stratified cluster sampling was performed to select 2 178 healthy children aged 0-18 years in the districts of Futian, Luohu, Nanshan, Bao'an, and Longgang in Shenzhen between September 2015 and September 2016. There were 1 219 boys and 959 girls, including 81 neonates, 335 infants, 346 young children, 469 preschool children, 419 school-aged children, and 528 adolescents. The American Beckman DXI800 chemiluminescence meter was used to measure the levels of luteinizing hormone, follicle-stimulating hormone, progesterone, prolactin, estradiol, and testosterone. Results There were significant differences in the levels of luteinizing hormone, follicle-stimulating hormone, progesterone, prolactin, estradiol, and testosterone between different age groups (P < 0.05). There were also significant differences in the levels of these sex hormones between boys and girls in the same age group (P < 0.05). The reference ranges of six sex hormones were established for healthy children aged 0-18 years in Shenzhen based on the levels of these hormones in different age groups. Conclusions There are significant differences in sex hormones between different age groups or sex groups. The reference ranges of six sex hormones established for different sexes or ages have great significance in the diagnosis and treatment of endocrine diseases in children.
SUN Li-Fang,LI Ying-Ying,HUANG Bao-Xing et al. Establishment of reference ranges of sex hormones for healthy children in Shenzhen, China based on chemiluminescence[J]. CJCP, 2017, 19(12): 1257-1262.
SUN Li-Fang,LI Ying-Ying,HUANG Bao-Xing et al. Establishment of reference ranges of sex hormones for healthy children in Shenzhen, China based on chemiluminescence[J]. CJCP, 2017, 19(12): 1257-1262.
Konforte D, Shea JL, Kyriakopoulou L, et al. Complex biological pattern of fertility hormones in children and adolescents:a study of healthy children from the CALIPER cohort and establishment of pediatric reference intervals[J]. Clin Chem, 2013, 59(8):1215-1227.
[9]
CLSI. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guidelines, CLSI Document C28-A3[S]. Wayne, PA:Clinical and Laboratory Standards Institute, 2008.
Koskas T, Souaré K, Ouahabi T, et al. Reference intervals for follicle-stimulating hormone, luteinizing hormone and prolactin in children and young adults on the bioMerieux Mini-Vidas system[J]. Clin Chem Lab Med, 2007, 45(4):541-545.
[14]
Elmlinger MW, Kühnel W, Ranke MB. Reference ranges for serum concentrations of lutropin (LH), follitropin (FSH), estradiol (E2), prolactin, progesterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), cortisol and ferritin in neonates, children and young adults[J]. Clin Chem Lab Med, 2002, 40(11):1151-1160.
Lee PA, Jaffe RB, Midgley AR Jr. Serum gonadotropin, testosterone and prolactin concentrations throughout puberty in boys:a longitudinal study[J]. J Clin Endocrinol Metab, 1974, 39(4):664-672.
