Research advances in the association between transient receptor potential cation channel 6 and kidney disease

CAO Shan; LIU Yun-Guang

doi:10.7499/j.issn.1008-8830.2018.01.015

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Chinese Journal of Contemporary Pediatrics ›› 2018, Vol. 20 ›› Issue (1) : 72-76. DOI: 10.7499/j.issn.1008-8830.2018.01.015

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Research advances in the association between transient receptor potential cation channel 6 and kidney disease

CAO Shan¹, LIU Yun-Guang²

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Abstract

Transient receptor potential cation channel 6 (TRPC6) is a member of the transient receptor superfamily encoded by the TRPC6 gene and is widely expressed in tissues and organs of the human body, especially in the glomerular podocytes. TRPC6 interacts with various slit diaphragm (SD) proteins including podocin, nephrin, ACTN4, and CD2AP to maintain the normal structure and function of glomerular podocytes. Foot process fusion caused by podocyte damage due to various factors is the most important morphological change in kidney disease. This article reviews the biological function of TRPC6 and its effect on kidney disease.

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Transient receptor potential cation channel 6 / Podocyte / Kidney disease

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CAO Shan, LIU Yun-Guang. Research advances in the association between transient receptor potential cation channel 6 and kidney disease[J]. Chinese Journal of Contemporary Pediatrics. 2018, 20(1): 72-76 https://doi.org/10.7499/j.issn.1008-8830.2018.01.015

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