Role of programmed death-1 in viral infectious diseases

LU Fu-Ce; NONG Guang-Min

doi:10.7499/j.issn.1008-8830.2018.01.016

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Chinese Journal of Contemporary Pediatrics ›› 2018, Vol. 20 ›› Issue (1) : 77-82. DOI: 10.7499/j.issn.1008-8830.2018.01.016

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Role of programmed death-1 in viral infectious diseases

LU Fu-Ce, NONG Guang-Min

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Abstract

The research on the immunoregulatory effect of programmed death-1 (PD-1) in infectious diseases mainly focuses on chronic viral infection, but there are few studies on acute viral infection. In chronic viral infection, PD-1 is highly expressed on the surface of CD8⁺ T cells, which is a sign of CD8⁺ T cell depletion. Recent studies have shown that in chronic viral infection, PD-1 is also highly expressed on the surface of regulatory T cells and binds to programmed death-ligand 1 (PD-L1) on the surface of exhausted CD8⁺ T cells, resulting in a stronger inhibitory effect on CD8⁺ T cell immunity. Blocking the PD-1/PD-L1 signaling pathway between exhausted CD8⁺ T cells and regulatory T cells can significantly reverse the depletion of CD8⁺ T cells and greatly improve the antiviral effect of CD8⁺ T cells. However, the role of the PD-1/PD-L1 signaling pathway in acute viral infection remains unknown. This article summarizes the latest research on PD-1 in infectious diseases and discusses its role in acute and chronic viral infection.

Key words

Programmed death-1 / Viral infection / Regulatory T cell / Exhausted CD8⁺ T cell

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LU Fu-Ce, NONG Guang-Min. Role of programmed death-1 in viral infectious diseases[J]. Chinese Journal of Contemporary Pediatrics. 2018, 20(1): 77-82 https://doi.org/10.7499/j.issn.1008-8830.2018.01.016

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