Abstract Objective To investigate the effect of early rehabilitation intervention on the incidences of extrauterine growth retardation (EUGR) and early diseases in preterm infants.Methods The appropriate-for-gestational-age preterm infants with a gestational age of < 34 weeks and a birth weight of 1 000 to < 2 000 g who were admitted to the neonatal intensive care unit (NICU) within 24 hours after birth were enrolled in a prospective randomized controlled trial. These infants were randomly divided into rehabilitation intervention group and control group. The infants in the rehabilitation intervention group were given early rehabilitation after their vital signs became stable, including oral sensory and muscle strength training and pressure touching of the head, chest, abdomen, extremities, hands, and feet. The primary outcome measures were the time to independent oral feeding, length of hospital stay, and incidence rate of EUGR. The secondary outcome measures were the incidence rates of related diseases in preterm infants, such as apnea, feeding intolerance, and sepsis.Results A total of 97 preterm infants who met the inclusion criteria and had complete data were enrolled, with 48 in the control group and 49 in the rehabilitation intervention group. The rehabilitation intervention group had a shorter time to independent oral feeding than the control group (P < 0.05). Compared with the control group, the rehabilitation intervention group had a shorter length of hospital stay and a lower corrected gestational age at discharge (P < 0.05), as well as a lower incidence rate of EUGR (P < 0.05). The rehabilitation intervention group had lower incidence rates of apnea, feeding intolerance, and sepsis than the control group (P < 0.05).Conclusions Early rehabilitation intervention for preterm infants in the NICU may reduce the incidence rates of apnea, feeding intolerance, and EUGR and help them to achieve independent oral feeding early.
NI Wen-Si,ZHANG Yong-Hong,LI Ting et al. Early rehabilitation intervention reduces the incidence of extrauterine growth retardation in preterm infants[J]. CJCP, 2018, 20(2): 97-101.
NI Wen-Si,ZHANG Yong-Hong,LI Ting et al. Early rehabilitation intervention reduces the incidence of extrauterine growth retardation in preterm infants[J]. CJCP, 2018, 20(2): 97-101.
Field T, Diego MA, Hernandez-Reif M, et al. Moderate versus light pressure massage therapy leads to greater weight gain in preterm infants[J]. Infant Behav Dev, 2006, 29(4):574-578.
[2]
Tekgündüz KŞ, Gürol A, Apay SE, et al. Effect of abdomen massage for prevention of feeding intolerance in preterm infants[J]. Ital J Pediatr, 2014, 40(14):89-94.
[3]
Fucile S, Gisel EG, McFarland DH, et al. Oral and non-oral sensorimotor interventions enhance oral feeding performance in preterm infants[J]. Dev Med Child Neurol, 2011, 53(9):829-835.
[4]
Kumar J, Upadhyay A, Dwivedi AK, et al. Effect of oil massage on growth in preterm neonates less than 1800 g:a randomized control trial[J]. Indian J Pediatr, 2013, 80(6):465-469.
Fenton TR, Kim JH. A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants[J]. BMC Pediatr, 2013, 13:59.
[8]
Fucile S, McFarland DH, Gisel EG, et al. Oral and nonoral sensorimotor interventions facilitate suck-swallow-respiration functions and their coordination in preterm infants[J]. Early Hum Dev, 2012, 88(6):345-350.
[9]
Diego MA, Field T, Hernandez-Reif M. Preterm infant weight gain is increased by massage therapy and exercise via different underlying mechanisms[J]. Early Hum Dev, 2014, 90(3):137-140.
[10]
Mendes EW, Procianoy RS. Massage therapy reduces hospital stay and occurrence of late-onset sepsis in very preterm neonates[J]. J Perinatol, 2008, 28(12):815-820.
[11]
Pepino VC, Mezzacappa MA. Application of tactile/kinesthetic stimulation in preterm infants:a systematic review[J]. J Pediatr (Rio J), 2015, 91(3):213-233.
