Abstract Objective To study the risk factors for elevated serum total bile acid (TBA) in preterm infants. Methods A retrospective analysis was performed for the clinical data of 216 preterm infants who were admitted to the neonatal intensive care unit. According to the presence or absence of elevated TBA (TBA > 24.8 μmol/L), the preterm infants were divided into elevated TBA group with 53 infants and non-elevated TBA group with 163 infants. A univariate analysis and an unconditional multivariate logistic regression analysis were used to investigate the risk factors for elevated TBA. Results The univariate analysis showed that there were significant differences between the elevated TBA group and the non-elevated TBA group in gestational age at birth, birth weight, proportion of small-for-gestational-age infants, proportion of infants undergoing ventilator-assisted ventilation, fasting time, parenteral nutrition time, and incidence of neonatal respiratory failure and sepsis (P < 0.05). The unconditional multivariate logistic regression analysis showed that low birth weight (OR=3.84, 95% CI:1.53-9.64) and neonatal sepsis (OR=2.56, 95% CI:1.01-6.47) were independent risk factors for elevated TBA in preterm infants. Conclusions Low birth weight and neonatal sepsis may lead to elevated TBA in preterm infants.
Li T, Apte U. Bile acid metabolism and signaling in cholestasis, inflammation, and cancer[J]. Adv Pharmacol, 2015, 74:263-302.
[3]
Polkowska G, Polkowski W, Kudlicka A, et al. Range of serum bile acid concentrations in neonates, infants, older children, and in adults[J]. Med Sci Monit, 2001, 7(Suppl 1):268-270.
Burrin DG, Ng K, Stoll B, et al. Impact of new-generation lipid emulsions on cellular mechanisms of parenteral nutrition-associated liver disease[J]. Adv Nutr, 2014, 5(1):82-91.
Costa S, Maggio L, Sindico P, et al. Preterm small for gestational age infants are not at higher risk for parenteral nutrition-associated cholestasis[J]. J Pediatr, 2010, 156(4):575-579.
