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Advances in the diagnosis and treatment of pediatric acute respiratory distress syndrome
CHEN Yang, LU Guo-Ping
Chinese Journal of Contemporary Pediatrics ›› 2018, Vol. 20 ›› Issue (9) : 717-723.
PDF(1080 KB)
PDF(1080 KB)
Advances in the diagnosis and treatment of pediatric acute respiratory distress syndrome
Pediatric acute respiratory distress syndrome (ARDS) is an important cause of deaths in critically ill children admitted to the pediatric intensive care unit. Although lung-protective ventilation improves the prognosis of pediatric ARDS, the mortality rate of children with moderate or severe ARDS is still high. Given that the epidemiology, treatment, and prognosis of pediatric ARDS are different from those of adult ARDS, pediatric ARDS was first defined in the 2015 Pediatric Acute Lung Injury Consensus Conference. Early diagnosis and appropriate clinical management of ARDS are still great challenges for pediatric critical care medicine. This paper focuses on the definition, epidemiology, and management of pediatric ARDS.
Acute respiratory distress syndrome / Lung-protective ventilation / Child
[1] Wong JJ, Loh TF, Testoni D, et al. Epidemiology of pediatric acute respiratory distress syndrome in Singapore:risk factors and predictive respiratory indices for mortality[J]. Front Pediatr, 2014, 2:78.
[2] Ashbaugh DG, Bigelow DB, Petty TL, et al. Acute respiratory distress in adults[J]. Lancet, 1967, 290(7511):319-323.
[3] Bernard GR, Artigas A, Brigham KL, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination[J]. Am J Respir Crit Care Med, 1994, 149(3 Pt 1):818-824.
[4] ARDS Definition Task Force; Ranieri VM, Rubenfeld GD, Thompsonet BT, et al. Acute respiratory distress syndrome:the Berlin Definition[J]. JAMA, 2012, 307(23):2526-2533.
[5] Murray JF, Matthay MA, Luce JM, et al. An expanded definition of the adult respiratory distress syndrome[J]. Am Rev Respir Dis, 1988, 138(3):720-723.
[6] Hammer J, Numa A, Newth CJ. Acute respiratory distress syndrome caused by respiratory syncytial virus[J]. Pediatr Pulmonol, 1997, 23(3):176-183.
[7] Pediatric Acute Lung Injury Consensus Conference Group. Pediatric acute respiratory distress syndrome:consensus recommendations from the Pediatric Acute Lung Injury Consensus Conference[J]. Pediatr Crit Care Med, 2015, 16(5):428-439.
[8] Yu WL, Lu ZJ, Wang Y, et al. The epidemiology of acute respiratory distress syndrome in pediatric intensive care units in China[J]. Intensive Care Med, 2009, 35(1):136-143.
[9] Wong JJ, Jit M, Sultana R, et al. Mortality in pediatric acute respiratory distress syndrome:a systematic review and meta-analysis[J]. J Intensive Care Med, 2017:885066617705109.
[10] Bellani G, Laffey JG, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries[J]. JAMA, 2016, 315(8):788-800.
[11] Kneyber MCJ, de Luca D, Calderini E, et al. Recommendations for mechanical ventilation of critically ill children from the Paediatric Mechanical Ventilation Consensus Conference (PEMVECC)[J]. Intensive Care Med, 2017, 43(12):1764-1780.
[12] Acute Respiratory Distress Syndrome Network; Brower RG, Matthay MA, Morris A, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome[J]. N Engl J Med, 2000, 342(18):1301-1308.
[13] Erickson S, Schibler A, Numa A, et al. Acute lung injury in pediatric intensive care in Australia and New Zealand:a prospective, multicenter, observational study[J]. Pediatr Crit Care Med, 2007, 8(4):317-323.
[14] Khemani RG, Parvathaneni K, Yehya N, et al. Positive end-expiratory pressure lower than the ARDS network protocol is associated with higher pediatric acute respiratory distress syndrome mortality[J]. Am J Respir Crit Care Med, 2018, 198(1):77-89.
[15] Fuchs H, Rossmann N, Schmid MB, et al. Permissive hypercapnia for severe acute respiratory distress syndrome in immunocompromised children:a single center experience[J]. PLoS One, 2017, 12(6):e0179974.
[16] 王小亭, 刘大为, 张宏民, 等. 重症右心功能管理专家共识[J]. 中华内科杂志, 2017, 56(12):962-973.
[17] Morrow B, Futter M, Argent A. A recruitment manoeuvre performed after endotracheal suction does not increase dynamic compliance in ventilated paediatric patients:a randomised controlled trial[J]. Aust J Physiother, 2007, 53(3):163-169.
[18] Sklar MC, Fan E, Goligher EC. High-frequency oscillatory ventilation in adults with ARDS:past, present, and future[J]. Chest, 2017, 152(6):1306-1317.
[19] Bateman ST, Borasino S, Asaro LA, et al. Early high-frequency oscillatory ventilation in pediatric acute respiratory failure. A propensity score analysis[J]. Am J Respir Crit Care Med, 2016, 193(5):495-503.
[20] Rowan CM, Loomis A, McArthur J, et al. High-frequency oscillatory ventilation use and severe pediatric ARDS in the pediatric hematopoietic cell transplant recipient[J]. Respir Care, 2018, 63(4):404-411.
[21] Rimensberger PC, Cheifetz IM; Pediatric Acute Lung Injury Consensus Conference Group. Ventilatory support in children with pediatric acute respiratory distress syndrome:proceedings from the Pediatric Acute Lung Injury Consensus Conference[J]. Pediatr Crit Care Med, 2015, 16(5 Suppl 1):S51-S60.
[22] Karam O, Gebistorf F, Wetterslev J, et al. The effect of inhaled nitric oxide in acute respiratory distress syndrome in children and adults:a Cochrane Systematic Review with trial sequential analysis[J]. Anaesthesia, 2017, 72(1):106-117.
[23] Tamburro RF, Kneyber MC; Pediatric Acute Lung Injury Consensus Conference Group. Pulmonary specific ancillary treatment for pediatric acute respiratory distress syndrome:proceedings from the Pediatric Acute Lung Injury Consensus Conference[J]. Pediatr Crit Care Med, 2015, 16(5 Suppl 1):S61-S72.
[24] Bronicki RA, Fortenberry J, Schreiber M, et al. Multicenter randomized controlled trial of inhaled nitric oxide for pediatric acute respiratory distress syndrome[J]. J Pediatr, 2015, 166(2):365-369. e1.
[25] Willson DF, Thomas NJ, Markovitz BP, et al. Effect of exogenous surfactant (calfactant) in pediatric acute lung injury:a randomized controlled trial[J]. JAMA, 2005, 293(4):470-476.
[26] Czaja AS. A critical appraisal of a randomized controlled trial:Willson et al:Effect of exogenous surfactant (calfactant) in pediatric acute lung injury (JAMA 2005, 293:470-476)[J]. Pediatr Crit Care Med, 2007, 8(1):50-53.
[27] Thomas NJ, Guardia CG, Moya FR, et al. A pilot, randomized, controlled clinical trial of lucinactant, a peptide-containing synthetic surfactant, in infants with acute hypoxemic respiratory failure[J]. Pediatr Crit Care Med, 2012, 13(6):646-653.
[28] Bloomfield R, Noble DW, Sudlow A. Prone position for acute respiratory failure in adults[J]. Cochrane Database Syst Rev, 2015(11):CD008095.
[29] Kallet RH. A comprehensive review of prone position in ARDS[J]. Respir Care, 2015, 60(11):1660-1687.
[30] Fan E, Del Sorbo L, Goligher EC, et al. An official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine clinical practice guideline:mechanical ventilation in adult patients with acute respiratory distress syndrome[J]. Am J Respir Crit Care Med, 2017, 195(9):1253-1263.
[31] Tillmann BW, Klingel ML, Iansavichene AE, et al. Extracorporeal membrane oxygenation (ECMO) as a treatment strategy for severe acute respiratory distress syndrome (ARDS) in the low tidal volume era:a systematic review[J]. J Crit Care, 2017, 41:64-71.
[32] Barbaro RP, Xu Y, Borasino S, et al. Does extracorporeal membrane oxygenation improve survival in pediatric acute respiratory failure?[J]. Am J Respir Crit Care Med, 2018, 197(9):1177-1186.
[33] Lin JC. Extracorporeal membrane oxygenation for severe pediatric respiratory failure[J]. Respir Care, 2017, 62(6):732-750.
[34] Dalton HJ, Macrae DJ; Pediatric Acute Lung Injury Consensus Conference Group. Extracorporeal support in children with pediatric acute respiratory distress syndrome:proceedings from the Pediatric Acute Lung Injury Consensus Conference[J]. Pediatr Crit Care Med, 2015, 16(5 Suppl 1):S111-S117.
[35] Papazian L, Forel JM, Gacouin A, et al. Neuromuscular blockers in early acute respiratory distress syndrome[J]. N Engl J Med, 2010, 363(12):1107-1116.
[36] Sweeney RM, McAuley DF. Acute respiratory distress syndrome[J]. Lancet, 2016, 388(10058):2416-2430.
[37] Wong JJ, Han WM, Sultana R, et al. Nutrition delivery affects outcomes in pediatric acute respiratory distress syndrome[J]. JPEN J Parenter Enteral Nutr, 2017, 41(6):1007-1013.
