Significance of NUDT15 gene in individualized treatment with 6-mercaptopurine in children with acute lymphoblastic leukemia

HE Jing; LIU Ling

doi:10.7499/j.issn.1008-8830.2019.01.018

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Chinese Journal of Contemporary Pediatrics ›› 2019, Vol. 21 ›› Issue (1) : 100-104. DOI: 10.7499/j.issn.1008-8830.2019.01.018

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Significance of NUDT15 gene in individualized treatment with 6-mercaptopurine in children with acute lymphoblastic leukemia

HE Jing, LIU Ling

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Abstract

As an important drug during maintenance treatment of acute lymphoblastic leukemia (ALL), 6-mercaptopurine (6-MP) has several side effects, including hepatotoxicity and bone marrow suppression. Since its tolerability varies from person to person, 6-MP treatment should be individualized. The deficiency of thiopurine methyltransferase (TPMT) enzyme activity is associated with 6-MP intolerance. There is a lower frequency of mutation in TPMT alleles among Asian patients. Recent studies have shown that in ALL patients with NUDT15 gene mutation, the maximum tolerated dose of 6-MP is lower than the conventional dose. The article reviews the significance of NUDT15 gene in individualized treatment with 6-MP in children with ALL.

Key words

Acute lymphoblastic leukemia / NUDT15 / 6-Mercaptopurine

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HE Jing, LIU Ling. Significance of NUDT15 gene in individualized treatment with 6-mercaptopurine in children with acute lymphoblastic leukemia[J]. Chinese Journal of Contemporary Pediatrics. 2019, 21(1): 100-104 https://doi.org/10.7499/j.issn.1008-8830.2019.01.018

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