安徽省住院早产儿脑损伤多中心流行病学调查

doi:10.7499/j.issn.1008-8830.2019.02.002

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Abstract Objective To investigate the risk factors for brain injury in preterm infants by a multicenter epidemiological investigation of brain injury in hospitalized preterm infants in Anhui, China. Methods Preterm infants who were hospitalized in the department of neonatology in 9 hospitals of Anhui Neonatal Collaboration Network between January 2016 and January 2017 were enrolled as subjects. The data of maternal pregnancy and clinical data of preterm infants were collected, and the logistic regression model was used to analyze the risk factors for brain injury in preterm infants. Results A total of 3 378 preterm infants were enrolled. Of the 3 378 preterm infants, 798 (23.56%) had periventricular-intraventricular hemorrhage (PVH-IVH), and 88 (2.60%) had periventricular leukomalacia (PVL). Intrauterine distress, anemia, hypoglycemia and necrotizing enterocolitis (NEC) were risk factors for PVH-IVH (OR=1.310, 1.591, 1.835, and 3.310 respectively; P < 0.05), while a higher gestational age was a protective factor against PVH-IVH (OR=0.671, P < 0.05). PVH-IVH, NEC and mechanical ventilation were risk factors for PVL (OR=4.017, 3.018, and 2.166 respectively; P < 0.05), and female sex and use of pulmonary surfactant were protective factors against PVL (OR=0.514 and 0.418 respectively; P < 0.05). Conclusions Asphyxia/anoxia, infection/inflammation, mechanical ventilation, anemia and hypoglycemia may increase the risk of brain injury in preterm infants.

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	Articles by authors
	ZHANG Jian
	LIU Guang-Hui
	ZHAO Yu-Wei
	WANG Hui-Qin
	MAO Shuang-Gen
	MAO Guo-Shun
	XI Kang-Ming
	WANG Li-Li
	ZHANG Chuan-Long
	GAO Cheng-Ju
	HUANG Dao-Dan

Key words： Periventricular-intraventricular hemorrhage Periventricular leukomalacia Risk factor Preterm infant

Received: 19 October 2018

Corresponding Authors: 刘光辉,男,主任医师,教授。Email:lgh508@sina.com E-mail: lgh508@sina.com

Cite this article:

ZHANG Jian,LIU Guang-Hui,ZHAO Yu-Wei et al. A multicenter epidemiological investigation of brain injury in hospitalized preterm infants in Anhui, China[J]. CJCP, 2019, 21(2): 114-119.

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http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2019.02.002 OR http://www.zgddek.com/EN/Y2019/V21/I2/114

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