CJCP
  中文版
  English Version
 
CJCP  2019, Vol. 21 Issue (6): 522-527    DOI: 10.7499/j.issn.1008-8830.2019.06.005
CLINICAL RESEARCH Current Issue| Next Issue| Archive| Adv Search  | 
Application of dexmedetomidine in children with agitation during ventilator weaning
HE Jie, ZHANG Xin-Ping, YANG Mei-Yu, YUAN Yuan-Hong, ZHOU Xiong, ZHAO Wen-Jiao, XIAO Zheng-Hui
Emergency Center, Hunan Children's Hospital, Changsha 410007, China
Download: PDF (1289 KB)   HTML(72)
Export: BibTeX | EndNote (RIS)      Supporting Info
Abstract  Objective To study the clinical effect and safety of dexmedetomidine in children with agitation during ventilator weaning. Methods A prospective open observational study was performed for children who were admitted to the intensive care unit and experienced mechanical ventilation between March 2017 and August 2018. They were given dexmedetomidine due to the failure in the spontaneous breathing test (SBT) caused by agitation. A sedation-agitation scale score of ≥ 5 was defined as agitation. The children were observed in terms of the sedation state at 0.5, 1, 2, 6, and 12 hours after the administration of dexmedetomidine, blood gas parameters before extubation and at 1, 24, and 48 hours after extubation, vital signs (heart rate, respiratory rate and mean arterial pressure) before SBT, before extubation, and at 10, 60, and 120 minutes and 24 hours after extubation, and incidence rates of adverse events related to the use of dexmedetomidine. Results A total of 19 children were enrolled in this study. All the children were in a state of agitation at the time of enrollment. At 0.5, 1, 2, 6, and 12 hours after the administration of dexmedetomidine, 12, 17, 17, 18, and 18 children respectively reached the sedation state. There were no significant differences in the oxygenation index, arterial partial pressure of carbon dioxide, heart rate, respiratory rate, and mean arterial pressure at each time point before and after extubation (P > 0.05). No adverse events were observed, such as severe hypotension and respiratory depression, and only one child experienced reversible bradycardia. Conclusions Dexmedetomidine is safe and effective in children with agitation during ventilator weaning, but prospective randomized controlled trials are needed for verification.
Service
E-mail this article
Add to my bookshelf
Add to citation manager
E-mail Alert
RSS
Articles by authors
HE Jie
ZHANG Xin-Ping
YANG Mei-Yu
YUAN Yuan-Hong
ZHOU Xiong
ZHAO Wen-Jiao
XIAO Zheng-Hui
Key wordsAgitation      Mechanical ventilation      Dexmedetomidine      Child     
Received: 28 December 2018     
Cite this article:   
HE Jie,ZHANG Xin-Ping,YANG Mei-Yu et al. Application of dexmedetomidine in children with agitation during ventilator weaning[J]. CJCP, 2019, 21(6): 522-527.
HE Jie,ZHANG Xin-Ping,YANG Mei-Yu et al. Application of dexmedetomidine in children with agitation during ventilator weaning[J]. CJCP, 2019, 21(6): 522-527.
URL:  
http://www.zgddek.com/EN/10.7499/j.issn.1008-8830.2019.06.005     OR     http://www.zgddek.com/EN/Y2019/V21/I6/522
Copyright © 2004-2005 Chinese Journal Of Contemporary Pediatrics All rights reserved.
Addr: 87 Xiangya Road, Changsha, Hunan, 410008, PRC
Tel: 0731-84327402 Fax: 0731-84327922 E-mail: cjcp1999@csu.edu.cn