Abstract Objective To investigate the physical development, incidence of common respiratory diseases, and motor development during infancy in preterm infants with bronchopulmonary dysplasia (BPD). Methods A retrospective analysis was performed on the clinical features and infantile outcomes of preterm infants with BPD who were admitted to the neonatal intensive care unit between January 2012 and December 2015. Preterm infants without BPD were used as controls who were admitted to the neonatal intensive care unit during the same period and had similar gestational age and birth weight. Physical development, number of hospital stays, the incidences of pneumonia and wheezing, and motor development during infancy were compared between the two groups. Results Compared with the control group, BPD infants had a significantly higher incidence of extrauterine growth retardation at discharge (48% vs 41%; P < 0.05); BPD infants were more susceptible to pneumonia, wheezing, eczema and rhinitis; BDP infants also had a significantly higher number of readmissions due to respiratory tract infection (P < 0.05). BPD infants had a significantly smaller head circumference than the control group at corrected ages of 3, 6, and 12 months (P < 0.05). BPD infants had significantly delayed gross, fine, and overall motor development than the control group at corrected ages of 6 and 9 months (P < 0.05). Conclusions Infants with BPD are susceptible to extrauterine growth retardation at discharge. Their head circumference growth is relatively slow. They are susceptible to pneumonia and wheezing during infancy. Moreover, they have delayed motor development when compared with those without BPD at corrected ages of 6 and 9 months.
WEI Hong-Ling,XING Yan,WU Hui et al. Prognosis of bronchopulmonary dysplasia in preterm infants: a follow-up during infancy[J]. CJCP, 2019, 21(7): 624-628.
WEI Hong-Ling,XING Yan,WU Hui et al. Prognosis of bronchopulmonary dysplasia in preterm infants: a follow-up during infancy[J]. CJCP, 2019, 21(7): 624-628.
Gough A, Linden M, Spence D, et al. Impaired lung function and health status in adult survivors of bronchopulmonary dysplasia[J]. Eur Respir J, 2014, 43(3):808-816.
[5]
Carraro S, Filippone M, Da Dalt L, et al. Bronchopulmonary dysplasia:the earliest and perhaps the longest lasting obstructive lung disease in humans[J]. Early Hum Dev, 2013, 89(Suppl 3):S3-S5.
[6]
Nordlund B, James A, Ebersjö C, et al. Differences and similarities between bronchopulmonary dysplasia and asthma in schoolchildren[J]. Pediatr Pulmonol, 2017, 52(9):1179-1186.
[7]
Gouin M, Nguyen S, Savagner C, et al. Severe bronchiolitis in infants born very preterm and neurodevelopmental outcome at 2 years[J]. Eur J Pediatr, 2013, 172:639-644.
[8]
Natarajan G, Pappas A, Shankaran S, et al. Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia:impact of the physiologic definition[J]. Early Hum Dev, 2012, 88(7):509-515.
[9]
Malavolti AM, Bassler D, Arlettaz-Mieth R, et al. Bronchopulmonary dysplasia-impact of severity and timing of diagnosis on neurodevelopment of preterm infants:a retrospective cohort study[J]. BMJ Paediatr Open, 2018, 2(1):e000165.
[10]
Jobe AH, Bancalari E. Bronchopulmonary dysplasia[J]. Am J Respir Crit Care Med, 2001, 163(7):1723-1729.
[11]
Tavasoli A, Azimi P, Montazari A. Reliability and validity of the Peabody Developmental Motor Scales-second edition for assessing motor development of low birth weight preterm infants[J]. Pediatr Neurol, 2014, 51(4):522-526.
[12]
Cheong JLY, Doyle LW. An update on pulmonary and neurodevelopmental outcomes of bronchopulmonary dysplasia[J]. Semin Perinatol, 2018, 42(7):478-484.
[13]
Theile AR, Radmacher PG, Anschutz TW, et al. Nutritional strategies and growth in extremely low birth weight infants with bronchopulmonary dysplasia over the past 10 years[J]. J Perinatol, 2012, 32(2):117-122.
[14]
Giannì ML, Roggero P, Colnaghi MR, et al. The role of nutrition in promoting growth in pre-term infants with bronchopulmonary dysplasia:a prospective non-randomised interventional cohort study[J]. BMC Pediatr, 2014, 14:235.
[15]
Natarajan G, Johnson YR, Brozanski B, et al. Postnatal weight gain in preterm infants with severe bronchopulmonary dysplasia[J]. Am J Perinatol, 2014, 31(3):223-230.
Jartti T, Gern JE. Role of viral infections in the development and exacerbation of asthma in children[J]. J Allergy Clin Immunol, 2017, 140(4):895-906.
[18]
Szabo SM, Gooch KL, Bibby MM, et al. The risk of mortality among young children hospitalized for severe respiratory syncytial virus infection[J]. Paediatr Respir Rev, 2013, 13(Suppl 2):S1-S8.
[19]
Oncel MY, Arayici S, Simsek GK, et al. Risk factors for hospitalization due to lower respiratory tract infection in preterm infants on palivizumab prophylaxis[J]. Iran J Pediatr, 2013, 23(6):693-700.
[20]
Davidson LM, Berkelhamer SK. Bronchopulmonary dysplasia:chronic lung disease of infancy and long-term pulmonary outcomes[J]. J Clin Med, 2017, 6(1). pii:E4.
[21]
Hill DA, Spergel JM. The atopic march:critical evidence and clinical relevance[J]. Ann Allergy Asthma Immunol, 2018, 120(2):131-137.
[22]
Gonçalves C, Wandalsen G, Lanza F, et al. Repercussions of preterm birth on symptoms of asthma, allergic diseases and pulmonary function, 6-14 years later[J]. Allergol Immunopathol (Madr), 2016, 44(6):489-496.
[23]
Goedicke-Fritz S, Härtel C, Krasteva-Christ G, et al. Preterm birth affects the risk of developing immune-mediated diseases[J]. Front Immunol, 2017, 8:1266.
[24]
Griffiths A, Toovey R, Morgan PE, et al. Psychometric properties of gross motor assessment tools for children:a systematic review[J]. BMJ Open, 2018, 8(10):e021734.
[25]
Gou X, Yang L, Pan L, et al. Association between bronchopulmonary dysplasia and cerebral palsy in children:a meta-analysis[J]. BMJ Open, 2018, 8(9):e020735.
[26]
Kazibwe NJ, Veeranki PS, Smith KE. Cognitive skills in preterm infants with bronchopulmonary dysplasia at 1 year adjusted and 2 years chronological age[J]. J Matern Fetal Neonatal Med, 2018:1-5.