Abstract Objective To investigate the pathogen composition and clinical features of preterm infants with sepsis, and to provide a basis for early identification and treatment of sepsis in preterm infants. Methods A retrospective analysis was performed for the clinical data of 371 preterm infants with sepsis who had a positive blood culture between January 2014 and May 2018. According to the time of onset, the preterm infants were divided into an early-onset group (an age of onset of Results There was a higher proportion of infants with Klebsiella pneumoniae infection in the late-onset group (P Escherichia coli, Streptococcus agalactiae or Listeria infection in the early-onset group (P P P P P Conclusions Preterm infants with sepsis lack typical clinical manifestations and laboratory examination results at the time of onset. There are certain differences in pathogen composition and clinical features between preterm infants with early-and late-onset sepsis. Possible pathogens for sepsis should be considered based on age in days at the time of onset and related clinical features.
Dong Y, Speer CP, Glaser K. Beyond sepsis:Staphylococcus epidermidis is an underestimated but significant contributor to neonatal morbidity[J]. Virulence, 2018, 9(1):621-633.
Jiang JH, Chiu NC, Huang FY, et al. Neonatal sepsis in the neonatal intensive care unit:characteristics of early versus late onset[J]. J Microbiol Immunol Infect, 2004, 37(5):301-306.
Collado MC, Cernada M, Neu J, et al. Factors influencing gastrointestinal tract and microbiota immune interaction in preterm infants[J]. Pediatr Res, 2015, 77(6):726-731.
[13]
Lu Q, Duan H, Yu J, et al. Are global coagulation and platelet parameters useful markers for predicting late-onset neonatal sepsis?[J]. Clin Lab, 2016, 62(1-2):73-79.
Covington EW, Roberts MZ, Dong J. Procalcitonin monitoring as a guide for antimicrobial therapy:a review of current literature[J]. Pharmacotherapy, 2018, 38(5):569-581.
