Risk factors for cow's milk protein allergy in infants: a multicenter survey
ZHANG Ji-Yong1, ZHOU Shao-Ming2, WANG Shao-Hua3, SUI Feng-Xuan4, GAO Wu-Hong5, LIU Qing6, CAI Hua-Bo2, JIANG Hong-Ying1, LI Wei-Yan1, WANG Li-Ting1, LI Li6, ZHAO Wei6, YING Jing4, WU Qian-Zhen1, WENG Bi-Xia1, ZENG Yong-Mei1
Department of Pediatrics, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, Guangdong 518017, China
Abstract Objective To investigate the risk factors for cow's milk protein allergy (CMPA) among infants through a multicenter clinical study. Methods A total of 1 829 infants, aged 1-12 months, who attended the outpatient service of the pediatric department in six hospitals in Shenzhen, China from June 2016 to May 2017 were enrolled as subjects. A questionnaire survey was performed to screen out suspected cases of CMPA. Food avoidance and oral food challenge tests were used to make a confirmed diagnosis of CMPA CMPA. A multivariate logistic regression analysis was used to investigate the risk factors for CMPA. Results Among the 1 829 infants, 82 (4.48%) were diagnosed with CMPA. The multivariate logistic regression analysis showed that maternal food allergy (OR=4.91, 95% CI:2.24-10.76, P OR=3.18, 95% CI:1.32-7.65, P OR=3.55, 95% CI:1.52-8.27, P OR=0.21, 95% CI:0.08-0.58, P 6 months (OR=0.38, 95% CI:0.17-0.86, P Conclusions The introduction of complementary food at an age of < 4 months, maternal food allergy, and antibiotic exposure during pregnancy are risk factors for CMPA in infants.
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