Clinical features and chest CT findings of coronavirus disease 2019 in infants and young children
ZHOU Yun, YANG Gen-Dong, FENG Kai, HUANG Hua, YUN Yong-Xing, MOU Xin-Yan, WANG Li-Fei
Department of Radiology, Shenzhen Third People's Hospital/National Clinical Research Center for Infectious Diseases/Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong 518100, China
Abstract Objective To study the clinical features and chest CT findings of coronavirus disease 2019 (COVID-19) in infants and young children. Methods A retrospective analysis was performed for the clinical data and chest CT images of 9 children, aged 0 to 3 years, who were diagnosed with COVID-19 by nucleic acid detection between January 20 and February 10, 2020. Results All 9 children had an epidemiological history, and family clustering was observed for all infected children. Among the 9 children with COVID-19, 5 had no symptoms, 4 had fever, 2 had cough, and 1 had rhinorrhea. There were only symptoms of the respiratory system. Laboratory examination showed no reductions in leukocyte or lymphocyte count. Among the 9 children, 6 had an increase in lymphocyte count and 2 had an increase in leukocyte count. CT examination showed that among the 9 children, 8 had pulmonary inflammation located below the pleura or near the interlobar fissure and 3 had lesions distributed along the bronchovascular bundles. As for the morphology of the lesions, 6 had nodular lesions and 7 had patchy lesions; ground glass opacity with consolidation was observed in 6 children, among whom 3 had halo sign, and there was no typical paving stone sign. Conclusions Infants and young children with COVID-19 tend to have mild clinical symptoms and imaging findings not as typical as those of adults, and therefore, the diagnosis of COVID-19 should be made based on imaging findings along with epidemiological history and nucleic acid detection. Chest CT has guiding significance for the early diagnosis of asymptomatic children.
ZHOU Yun,YANG Gen-Dong,FENG Kai et al. Clinical features and chest CT findings of coronavirus disease 2019 in infants and young children[J]. CJCP, 2020, 22(3): 215-220.
ZHOU Yun,YANG Gen-Dong,FENG Kai et al. Clinical features and chest CT findings of coronavirus disease 2019 in infants and young children[J]. CJCP, 2020, 22(3): 215-220.
Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China:a descriptive study[J]. Lancet, 2020, 395(10223):507-513.
[4]
Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China[J]. JAMA, 2020. DOI:10.1001/jama.2020.1585. Epub ahead of print.
[5]
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China[J]. Lancet, 2020, 395(10223):497-506.
[6]
Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of 2019 novel coronavirus infection in China[J/OL]. medRxiv. (2020-02-09)[2020-02-22]. https://doi.org/10.1101/2020.02.06.20020974.
